PANCE Flashcards: Blueprint-Aligned Diagnoses, Tests & Next Steps
Study diagnoses, tests, next steps and management with a source-linked PANCE deck organized by the January 2025 NCCPA blueprint.
על החפיסה הזו
Reviewed for 2026, this 600-card English deck follows the January 2025 NCCPA PANCE blueprint. Its two public tag axes let you switch between medical-content systems and exam-task retrievals: discriminating history and examination cues, diagnosis, diagnostic-study choice, prevention, next-step intervention, pharmacotherapy, and selected foundations. Every answer links to a current first-party clinical guideline or authoritative public-health or professional body and records the 2026-08-26 review date. Official PANCE eligibility and certification requirements remain with NCCPA. No recalled or leaked exam questions, exam items, mark schemes, curriculum prose, commercial deck wording, logos, figures, or trade dress were copied. Educational review only. This deck isn't medical advice and isn't a substitute for current clinical guidance, supervision, local protocols, or patient-specific judgment. This independently written resource is unofficial and is not affiliated with or endorsed by NCCPA.
הכרטיסים בחפיסה הזו
כרטיס 1
שאלה
What core mechanism explains acute coronary syndrome?
תשובה
Plaque disruption with superimposed coronary thrombosis causes most acute coronary syndromes.
2025 ACC/AHA Guideline for the Management of Patients With Acute Coronary Syndromes · reviewed 2026-08-26
כרטיס 2
שאלה
When an adult patient with decision-making capacity refuses a recommended treatment, what is the clinician’s next step?
תשובה
Confirm that the choice is informed and voluntary, explain material risks and alternatives, document the discussion, and respect the refusal.
Informed Consent · reviewed 2026-08-26
כרטיס 3
שאלה
In a child or adolescent, what core mechanism explains asthma?
תשובה
Airway inflammation and hyperresponsiveness create variable, usually reversible airflow obstruction.
2026 GINA Strategy Report · reviewed 2026-08-26
כרטיס 4
שאלה
What core mechanism explains upper gastrointestinal bleeding?
תשובה
Bleeding proximal to the ligament of Treitz is altered by gastric acid and intestinal transit, producing hematemesis or melena.
ACG Clinical Guideline: Upper Gastrointestinal and Ulcer Bleeding · reviewed 2026-08-26
כרטיס 5
שאלה
In a child or adolescent, what core mechanism explains septic arthritis?
תשובה
Bacterial invasion of synovium triggers destructive inflammation that can rapidly damage cartilage.
Guideline for Management of Septic Arthritis in Native Joints · reviewed 2026-08-26
כרטיס 6
שאלה
What core mechanism explains acute ischemic stroke?
תשובה
Arterial occlusion deprives brain tissue of oxygen, leaving a salvageable penumbra around the infarct core.
2026 Guideline for the Early Management of Patients With Acute Ischemic Stroke · reviewed 2026-08-26
כרטיס 7
שאלה
What core mechanism explains community-acquired pneumonia?
תשובה
Alveolar infection fills air spaces with inflammatory exudate and impairs gas exchange.
Diagnosis and Treatment of Adults with Community-acquired Pneumonia · reviewed 2026-08-26
כרטיס 8
שאלה
What core mechanism explains ectopic pregnancy?
תשובה
Implantation outside the endometrial cavity, usually in the tube, can erode vessels and rupture.
Ectopic Pregnancy · reviewed 2026-08-26
כרטיס 9
שאלה
In a child or adolescent, what core mechanism explains major depressive disorder?
תשובה
Mood-network and stress-system dysregulation interacts with genetic and environmental vulnerability; no single neurotransmitter explains the disorder.
Clinical Practice Guideline for the Assessment and Treatment of Children and Adolescents With Major and Persistent Depressive Disorders · reviewed 2026-08-26
כרטיס 10
שאלה
What core mechanism explains type 2 diabetes mellitus?
תשובה
Insulin resistance plus progressive beta-cell dysfunction produces chronic hyperglycemia.
Standards of Care in Diabetes—2026 · reviewed 2026-08-26
כרטיס 11
שאלה
What core mechanism explains acute angle-closure glaucoma?
תשובה
Closure of the anterior-chamber angle blocks aqueous outflow and abruptly raises intraocular pressure.
Management of Angle-Closure Glaucoma · reviewed 2026-08-26
כרטיס 12
שאלה
What clinical clue should raise suspicion for aortic dissection?
תשובה
Abrupt severe chest or back pain, pulse or blood-pressure asymmetry, and a new aortic regurgitation murmur are high-risk clues.
2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease · reviewed 2026-08-26
כרטיס 13
שאלה
What core mechanism explains chronic kidney disease?
תשובה
Progressive nephron loss causes hyperfiltration in remaining nephrons, fibrosis, and multisystem toxin accumulation.
2024 CKD Evaluation and Management Guideline · reviewed 2026-08-26
כרטיס 14
שאלה
What core mechanism explains iron-deficiency anemia?
תשובה
Iron depletion limits heme synthesis, producing hypochromic microcytes and eventually tissue iron symptoms.
British Society of Gastroenterology Guidelines for the Management of Iron Deficiency Anaemia in Adults · reviewed 2026-08-26
כרטיס 15
שאלה
In an infant aged 1–23 months with a viral prodrome followed by cough, wheeze or crackles, tachypnea, and feeding difficulty, what is the most likely diagnosis?
תשובה
Bronchiolitis. An infant with viral prodrome followed by cough, wheeze or crackles, tachypnea, and feeding difficulty likely has bronchiolitis.
Bronchiolitis: Recommendations for Diagnosis, Monitoring and Management of Children One to 24 Months · reviewed 2026-08-26
כרטיס 16
שאלה
In a child or adolescent, what core mechanism explains atopic dermatitis?
תשובה
Skin-barrier dysfunction and type 2 inflammation increase transepidermal water loss and itch.
Atopic Dermatitis Clinical Guidelines · reviewed 2026-08-26
כרטיס 17
שאלה
What clinical clue should raise suspicion for acute pancreatitis?
תשובה
Severe persistent epigastric pain radiating to the back with nausea and vomiting is typical.
ACG Clinical Guideline: Management of Acute Pancreatitis · reviewed 2026-08-26
כרטיס 18
שאלה
What core mechanism explains uncomplicated cystitis?
תשובה
Ascending periurethral bacteria inflame the bladder mucosa without renal-parenchymal involvement.
EAU Guidelines on Urological Infections · reviewed 2026-08-26
כרטיס 19
שאלה
Which diagnosis causes symmetric synovitis of the MCP, PIP, or wrist joints with prolonged morning stiffness?
תשובה
Rheumatoid arthritis. Symmetric inflammatory pain and prolonged morning stiffness in MCP, PIP, or wrist joints with synovitis suggest rheumatoid arthritis.
Rheumatoid Arthritis · reviewed 2026-08-26
כרטיס 20
שאלה
What abilities are assessed when determining decision-making capacity for a specific choice?
תשובה
The patient must communicate a choice, understand relevant information, appreciate how it applies personally, and reason about the options.
Informed Consent · reviewed 2026-08-26
כרטיס 21
שאלה
Which diagnosis causes fluctuating, fatigable ptosis, diplopia, dysarthria, dysphagia, or proximal weakness that worsens with use?
תשובה
Myasthenia gravis. Fluctuating fatigable ptosis, diplopia, dysarthria, dysphagia, or proximal weakness that worsens with use suggests myasthenia.
International Consensus Guidance for Management of Myasthenia Gravis: 2020 Update · reviewed 2026-08-26
כרטיס 22
שאלה
Which diagnosis best fits new clinically significant diarrhea after antibiotics or healthcare exposure, especially with abdominal pain or leukocytosis?
תשובה
Clostridioides difficile infection. New clinically significant diarrhea after antibiotics or healthcare exposure, with abdominal pain or leukocytosis, suggests C. difficile.
2021 Focused Update Guidelines on Management of Clostridioides difficile Infection in Adults · reviewed 2026-08-26
כרטיס 23
שאלה
For surgical decision-making, after delivery of the head, retraction against the perineum and failure of the shoulders to deliver indicate which obstetric emergency?
תשובה
Shoulder dystocia. After delivery of the head, retraction against the perineum and failure of the shoulders to deliver indicates dystocia.
Shoulder Dystocia · reviewed 2026-08-26
כרטיס 24
שאלה
In a child or adolescent, which diagnosis causes persistent developmentally inappropriate inattention and/or hyperactivity-impulsivity in more than one setting with impairment?
תשובה
Attention-deficit/hyperactivity disorder. Persistent developmentally inappropriate inattention and/or hyperactivity-impulsivity in more than one setting with impairment suggests ADHD.
ADHD in Children and Youth: Part 1—Etiology, Diagnosis, and Comorbidity · reviewed 2026-08-26
כרטיס 25
שאלה
Which diagnosis best fits sharp pleuritic chest pain that improves when sitting forward, a friction rub, and diffuse ST elevation?
תשובה
Acute pericarditis. Sharp pleuritic chest pain that improves when sitting forward, a friction rub, and diffuse ST elevation support pericarditis.
2025 Concise Clinical Guidance: Diagnosis and Management of Pericarditis · reviewed 2026-08-26
כרטיס 26
שאלה
Which next action matters most in acute respiratory distress syndrome?
תשובה
Treat the cause, ventilate with low tidal volumes and limited pressures, and use prone positioning for severe hypoxemia.
An Update on Management of Adult Patients with Acute Respiratory Distress Syndrome · reviewed 2026-08-26
כרטיס 27
שאלה
For surgical decision-making, identify the condition from this pattern: Proximal weakness, easy bruising, facial plethora, wide violaceous striae, osteoporosis, or difficult diabetes and hypertension are discriminating clues.
תשובה
Cushing syndrome. Proximal weakness, easy bruising, facial plethora, wide violaceous striae, osteoporosis, or difficult diabetes and hypertension are discriminating clues.
Diagnosis of Cushing Syndrome: An Endocrine Society Clinical Practice Guideline · reviewed 2026-08-26
כרטיס 28
שאלה
For surgical decision-making, identify the condition from this pattern: Severe unilateral sore throat, muffled voice, drooling, trismus, and uvular deviation suggest a peritonsillar collection.
תשובה
Peritonsillar abscess. Severe unilateral sore throat, muffled voice, drooling, trismus, and uvular deviation suggest a peritonsillar collection.
Tonsillitis and Peritonsillar Abscess · reviewed 2026-08-26
כרטיס 29
שאלה
What clinical clue should raise suspicion for anterior cruciate ligament tear?
תשובה
A noncontact pivot, audible pop, immediate swelling, and instability with a positive Lachman test suggest an ACL tear.
Management of Anterior Cruciate Ligament Injuries: Evidence-Based Clinical Practice Guideline · reviewed 2026-08-26
כרטיס 30
שאלה
Which diagnosis may be silent until edema, pruritus, anemia, hypertension, or abnormal urine testing appears?
תשובה
Chronic kidney disease. CKD may be silent; edema, pruritus, anemia, hypertension, or abnormal urine testing often appears later.
2024 CKD Evaluation and Management Guideline · reviewed 2026-08-26
כרטיס 31
שאלה
For surgical decision-making, which next action matters most in aortic dissection?
תשובה
Start rapid heart-rate and blood-pressure control and obtain emergency surgical evaluation for ascending dissection.
2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease · reviewed 2026-08-26
כרטיס 32
שאלה
Identify the condition from this pattern: Fatigue, pica, restless legs, koilonychia, or chronic blood loss can accompany microcytic anemia.
תשובה
Iron-deficiency anemia. Fatigue, pica, restless legs, koilonychia, or chronic blood loss can accompany microcytic anemia.
British Society of Gastroenterology Guidelines for the Management of Iron Deficiency Anaemia in Adults · reviewed 2026-08-26
כרטיס 33
שאלה
What clinical clue should raise suspicion for bacterial brain abscess?
תשובה
Headache, fever, focal deficit, seizure, or signs of raised intracranial pressure after sinus, ear, dental, or bloodstream infection raise suspicion.
ESCMID Guideline on Diagnosis and Treatment of Brain Abscess in Children and Adults · reviewed 2026-08-26
כרטיס 34
שאלה
Which diagnosis best fits chronic diarrhea, abdominal pain, weight loss, perianal disease, and skip lesions?
תשובה
Crohn disease. Chronic diarrhea, abdominal pain, weight loss, perianal disease, and skip lesions support Crohn disease.
Updated 2025 ACG Guidelines for Crohn’s Disease · reviewed 2026-08-26
כרטיס 35
שאלה
What clinical clue should raise suspicion for pulmonary tuberculosis?
תשובה
Chronic cough, fever, night sweats, weight loss, hemoptysis, or epidemiologic exposure raises concern.
Clinical Overview of Tuberculosis Disease · reviewed 2026-08-26
כרטיס 36
שאלה
Which diagnosis causes well-demarcated erythematous plaques with silvery scale on extensor surfaces and nail pitting?
תשובה
Plaque psoriasis. Well-demarcated erythematous plaques with silvery scale on extensor surfaces and nail pitting support psoriasis.
Psoriasis Clinical Guidelines · reviewed 2026-08-26
כרטיס 37
שאלה
What clinical clue should raise suspicion for endometriosis?
תשובה
Cyclic pelvic pain, dysmenorrhea, deep dyspareunia, painful defecation, or infertility suggests endometriosis.
Endometriosis · reviewed 2026-08-26
כרטיס 38
שאלה
Identify the condition from this pattern: Fever, flank pain, costovertebral-angle tenderness, nausea, and urinary symptoms suggest renal infection.
תשובה
Acute pyelonephritis. Fever, flank pain, costovertebral-angle tenderness, nausea, and urinary symptoms suggest renal infection.
EAU Guidelines on Urological Infections · reviewed 2026-08-26
כרטיס 39
שאלה
What clinical clue should raise suspicion for panic disorder?
תשובה
Recurrent unexpected panic attacks plus persistent worry or maladaptive avoidance for at least a month suggests panic disorder.
Panic Disorder: What You Need to Know · reviewed 2026-08-26
כרטיס 40
שאלה
What drug class or regimen fits acute pericarditis?
תשובה
Use an NSAID plus colchicine for uncomplicated acute pericarditis when not contraindicated.
2025 Concise Clinical Guidance: Diagnosis and Management of Pericarditis · reviewed 2026-08-26
כרטיס 41
שאלה
What clinical clue should raise suspicion for tension pneumothorax?
תשובה
Severe dyspnea, unilateral absent breath sounds, hypotension, distended neck veins, and obstructive shock suggest tension physiology.
Thoracic Trauma WSES-AAST Guidelines · reviewed 2026-08-26
כרטיס 42
שאלה
In a child or adolescent, which next action matters most in diabetic ketoacidosis?
תשובה
Begin isotonic fluids, replace potassium according to the measured level, and start IV insulin once potassium is safe.
Standards of Care in Diabetes—2026 · reviewed 2026-08-26
כרטיס 43
שאלה
Who makes decisions when an adult patient lacks capacity and has no applicable advance directive?
תשובה
Use the legally authorized surrogate and guide decisions by the patient’s known wishes or, if unknown, best interests.
Decisions for Adult Patients Who Lack Capacity · reviewed 2026-08-26
כרטיס 44
שאלה
For surgical decision-making, which next action matters most in retinal detachment?
תשובה
Send the patient to an eye doctor or emergency department immediately for retinal evaluation and treatment. Early treatment helps prevent permanent vision loss.
Retinal Detachment · reviewed 2026-08-26
כרטיס 45
שאלה
What clinical clue should raise suspicion for acute deep-vein thrombosis?
תשובה
Unilateral leg swelling, pain, warmth, and risk from immobility, surgery, cancer, estrogen, or prior VTE raise suspicion.
ASH VTE Guidelines: Diagnosis of Venous Thromboembolism · reviewed 2026-08-26
כרטיס 46
שאלה
Which next action matters most in Crohn disease?
תשובה
Drain abscesses and involve surgery for obstruction, fistula complications, perforation, or refractory disease.
Updated 2025 ACG Guidelines for Crohn’s Disease · reviewed 2026-08-26
כרטיס 47
שאלה
Which next action matters most in rheumatoid arthritis?
תשובה
Refer early and start disease-modifying therapy rather than relying on symptomatic treatment.
2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis · reviewed 2026-08-26
כרטיס 48
שאלה
What antimicrobial approach is appropriate for suspected or confirmed pleural infection?
תשובה
Start empiric antibiotics before culture results, covering likely organisms including anaerobes, then narrow therapy to microbiology and clinical context.
British Thoracic Society Guideline for Pleural Disease · reviewed 2026-08-26
כרטיס 49
שאלה
In a child or adolescent, which next action matters most in nephritic syndrome?
תשובה
Control pressure and volume, treat the cause, and obtain urgent nephrology input for rapidly progressive loss.
KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases with 2024 Chapter Updates · reviewed 2026-08-26
כרטיס 50
שאלה
Which prevention or risk-reduction step is important for acute coronary syndrome?
תשובה
Treat tobacco use, hypertension, diabetes, and dyslipidemia to reduce atherosclerotic risk.
2025 ACC/AHA Guideline for the Management of Patients With Acute Coronary Syndromes · reviewed 2026-08-26
כרטיס 51
שאלה
Which next action matters most in multiple sclerosis relapse?
תשובה
Exclude infection or pseudo-relapse, then treat functionally significant relapse and reassess disease-modifying therapy.
Multiple Sclerosis in Adults: Management · reviewed 2026-08-26
כרטיס 52
שאלה
Which next action matters most in HIV infection?
תשובה
Link a newly diagnosed patient rapidly to HIV care and begin antiretroviral therapy as soon as feasible.
Initiation of Antiretroviral Therapy · reviewed 2026-08-26
כרטיס 53
שאלה
For surgical decision-making, which next action matters most in postpartum hemorrhage?
תשובה
Call the hemorrhage team, massage an atonic uterus, give uterotonics, replace blood products, and control the cause procedurally if needed.
Postpartum Hemorrhage · reviewed 2026-08-26
כרטיס 54
שאלה
Which next action matters most in delirium?
תשובה
Treat the cause, protect the patient, and use nonpharmacologic measures first.
Delirium: Prevention, Diagnosis and Management · reviewed 2026-08-26
כרטיס 55
שאלה
After successful endoscopic hemostasis of a high-risk bleeding peptic ulcer, what medication strategy is recommended?
תשובה
Give high-dose proton-pump inhibitor therapy continuously or intermittently for 3 days.
ACG Clinical Guideline: Upper Gastrointestinal and Ulcer Bleeding · reviewed 2026-08-26
כרטיס 56
שאלה
What clinical clue should raise suspicion for thyroid storm?
תשובה
Fever, marked tachycardia, agitation or delirium, gastrointestinal symptoms, and heart failure in thyrotoxicosis suggest storm.
2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis · reviewed 2026-08-26
כרטיס 57
שאלה
In a child or adolescent, what drug class or regimen fits septic arthritis?
תשובה
Cover likely gram-positive organisms initially, adding gram-negative coverage for relevant risk.
Guideline for Management of Septic Arthritis in Native Joints · reviewed 2026-08-26
כרטיס 58
שאלה
What clinical clue should raise suspicion for acute bacterial rhinosinusitis?
תשובה
Persistent symptoms beyond 10 days, severe fever with purulent drainage, or worsening after initial improvement are patterns that support bacterial disease.
Clinical Practice Guideline: Adult Sinusitis Update · reviewed 2026-08-26
כרטיס 59
שאלה
How should a clinician respond when a patient asks not to hear serious diagnostic information?
תשובה
Explore the request and preferences, confirm it is voluntary, and identify whether the patient wants information shared with a chosen surrogate.
Withholding Information from Patients · reviewed 2026-08-26
כרטיס 60
שאלה
What is the key first diagnostic step for cardiac tamponade?
תשובה
Bedside echocardiography can show effusion with chamber collapse and respiratory flow variation.
2025 Concise Clinical Guidance: Diagnosis and Management of Pericarditis · reviewed 2026-08-26
כרטיס 61
שאלה
In a child or adolescent, which next action matters most in atopic dermatitis?
תשובה
Treat active inflammation and address infection, sleep disruption, and trigger exposure.
Atopic Dermatitis Clinical Guidelines · reviewed 2026-08-26
כרטיס 62
שאלה
What is the key first diagnostic step for idiopathic pulmonary fibrosis?
תשובה
High-resolution CT showing a usual interstitial pneumonia pattern can establish diagnosis in the right context; multidisciplinary review is key.
Idiopathic Pulmonary Fibrosis: An Update and Progressive Pulmonary Fibrosis in Adults · reviewed 2026-08-26
כרטיס 63
שאלה
What drug class or regimen fits benign prostatic hyperplasia?
תשובה
Alpha-1 blockers improve symptoms quickly; 5-alpha-reductase inhibitors reduce progression in appropriately enlarged prostates.
EAU Guidelines on the Management of Non-neurogenic Male Lower Urinary Tract Symptoms · reviewed 2026-08-26
כרטיס 64
שאלה
In a child or adolescent, what clinical clue should raise suspicion for nephritic syndrome?
תשובה
Hematuria with dysmorphic red cells or casts, hypertension, edema, and reduced kidney function suggests glomerular inflammation.
KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases with 2024 Chapter Updates · reviewed 2026-08-26
כרטיס 65
שאלה
In a child or adolescent, which initial medication regimen is indicated for a convulsive seizure lasting at least five minutes or recurring without recovery?
תשובה
A benzodiazepine is first-line for convulsive status epilepticus, followed by an appropriate longer-acting antiseizure medicine.
Treatment of Prolonged Seizures in Children and Adults · reviewed 2026-08-26
כרטיס 66
שאלה
Which next action matters most in acute deep-vein thrombosis?
תשובה
Start anticoagulation promptly after acute deep-vein thrombosis is confirmed, unless a contraindication changes the plan.
ASH VTE Guidelines: Treatment of Deep Vein Thrombosis and Pulmonary Embolism · reviewed 2026-08-26
כרטיס 67
שאלה
What drug class or regimen fits sepsis?
תשובה
Use broad therapy matched to source, host, and local resistance, then de-escalate from cultures and response.
2026 Surviving Sepsis Campaign Adult Guidelines · reviewed 2026-08-26
כרטיס 68
שאלה
Which bedside pattern best points to infective endocarditis?
תשובה
Fever plus a new or changing murmur, embolic findings, injection-drug use, or prosthetic material raises suspicion.
2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease · reviewed 2026-08-26
כרטיס 69
שאלה
What drug class or regimen fits pelvic inflammatory disease?
תשובה
Outpatient therapy commonly uses ceftriaxone plus doxycycline and metronidazole.
Pelvic Inflammatory Disease: STI Treatment Guidelines · reviewed 2026-08-26
כרטיס 70
שאלה
Which prevention or risk-reduction step is important for acute pancreatitis?
תשובה
Treat gallstones, avoid alcohol excess, and control severe hypertriglyceridemia to reduce recurrence.
ACG Clinical Guideline: Management of Acute Pancreatitis · reviewed 2026-08-26
כרטיס 71
שאלה
What drug class or regimen fits schizophrenia?
תשובה
Use an antipsychotic through shared decision-making; clozapine is indicated for treatment resistance or persistent suicide risk under monitoring.
Management of First-Episode Psychosis and Schizophrenia · reviewed 2026-08-26
כרטיס 72
שאלה
Which prevention or risk-reduction step is important for anterior cruciate ligament tear?
תשובה
Neuromuscular warm-up and landing programs reduce noncontact ACL injuries in high-risk athletes.
Management of Anterior Cruciate Ligament Injuries: Evidence-Based Clinical Practice Guideline · reviewed 2026-08-26
כרטיס 73
שאלה
What is the key first diagnostic step for primary hypothyroidism?
תשובה
Measure TSH first in most patients and free T4 to characterize overt disease.
Guidelines for the Treatment of Hypothyroidism · reviewed 2026-08-26
כרטיס 74
שאלה
In an acutely ill hospitalized medical patient, what VTE prevention strategy is appropriate?
תשובה
Assess VTE and bleeding risk, then use pharmacologic prophylaxis when indicated or mechanical prophylaxis when anticoagulation is unsuitable.
ASH VTE Guidelines: Prophylaxis for Medical Patients · reviewed 2026-08-26
כרטיס 75
שאלה
In a child aged 6 months or older, what drug class or regimen fits acute otitis media?
תשובה
Amoxicillin is first-line for most children who need an antibiotic, with alternatives guided by allergy and prior treatment.
Management of Acute Otitis Media in Children Six Months of Age and Older · reviewed 2026-08-26
כרטיס 76
שאלה
What makes informed consent more than a signed form?
תשובה
It is a communication process covering the nature, expected benefits, material risks, alternatives, and the option to decline, followed by a voluntary decision.
Informed Consent · reviewed 2026-08-26
כרטיס 77
שאלה
What condition should be suspected from this finding: Severely elevated pressure with acute neurologic, cardiac, renal, retinal, or aortic injury defines an emergency.
תשובה
Hypertensive emergency. Severely elevated pressure with acute neurologic, cardiac, renal, retinal, or aortic injury defines an emergency.
2025 High Blood Pressure Guideline · reviewed 2026-08-26
כרטיס 78
שאלה
Which prevention or risk-reduction step is important for migraine with aura?
תשובה
Regular sleep, meals, hydration, activity, trigger management, and limiting acute-medicine overuse reduce attacks.
AHS Consensus Statement: Integrating New Migraine Treatments into Clinical Practice · reviewed 2026-08-26
כרטיס 79
שאלה
What is the key first diagnostic step for upper gastrointestinal bleeding?
תשובה
Check hemodynamics, CBC, metabolic and coagulation studies, type and screen, then perform timely upper endoscopy after stabilization.
ACG Clinical Guideline: Upper Gastrointestinal and Ulcer Bleeding · reviewed 2026-08-26
כרטיס 80
שאלה
Which prevention or risk-reduction step is important for early syphilis?
תשובה
Condom use, partner services, repeat testing for ongoing risk, and prenatal screening reduce transmission and congenital disease.
Primary and Secondary Syphilis: STI Treatment Guidelines · reviewed 2026-08-26
כרטיס 81
שאלה
In a child or adolescent, what is the key first diagnostic step for septic arthritis?
תשובה
Perform urgent arthrocentesis for cell count, crystals, Gram stain, and culture; obtain blood cultures.
Guideline for Management of Septic Arthritis in Native Joints · reviewed 2026-08-26
כרטיס 82
שאלה
Which prevention or risk-reduction step is important for abnormal uterine bleeding from anovulation?
תשובה
Address reversible causes of ovulatory dysfunction, review medicines that worsen bleeding, and monitor for anemia.
Abnormal Uterine Bleeding · reviewed 2026-08-26
כרטיס 83
שאלה
In a young child, which diagnosis best fits a barking cough, hoarseness, and inspiratory stridor after a viral prodrome?
תשובה
Croup. Barking cough, hoarseness, and inspiratory stridor after a viral prodrome in a young child suggests croup.
Acute Management of Croup in the Emergency Department · reviewed 2026-08-26
כרטיס 84
שאלה
Which intervention is recommended to reduce later PTSD in an adult diagnosed with acute stress disorder?
תשובה
Offer individual trauma-focused cognitive behavioral psychotherapy with exposure and/or cognitive restructuring.
Management of Posttraumatic Stress Disorder and Acute Stress Disorder · reviewed 2026-08-26
כרטיס 85
שאלה
What clinical clue should raise suspicion for cellulitis?
תשובה
Unilateral expanding warmth, tenderness, erythema, and edema without a sharply raised border favor cellulitis.
Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections · reviewed 2026-08-26
כרטיס 86
שאלה
How should a clinician initially manage infective endocarditis?
תשובה
Start targeted IV antibiotics after cultures; seek early valve-team input for heart failure, uncontrolled infection, or major embolic risk.
2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease · reviewed 2026-08-26
כרטיס 87
שאלה
What clinical clue should raise suspicion for benign prostatic hyperplasia?
תשובה
Progressive weak stream, hesitancy, incomplete emptying, nocturia, and frequency suggest bladder-outlet symptoms.
EAU Guidelines on the Management of Non-neurogenic Male Lower Urinary Tract Symptoms · reviewed 2026-08-26
כרטיס 88
שאלה
What drug class or regimen fits chronic kidney disease?
תשובה
Use an ACE inhibitor or ARB for appropriate albuminuric CKD and an SGLT2 inhibitor for eligible patients.
2024 CKD Evaluation and Management Guideline · reviewed 2026-08-26
כרטיס 89
שאלה
Which microbiologic test is essential when gonococcal conjunctivitis is suspected?
תשובה
Obtain a conjunctival specimen for culture; add a locally validated nucleic-acid amplification test when available, and perform susceptibility testing on cultured isolates when indicated.
Gonococcal Infections Among Adolescents and Adults · reviewed 2026-08-26
כרטיס 90
שאלה
What drug class or regimen fits iron-deficiency anemia?
תשובה
Oral iron is first-line for many patients; IV iron is useful when absorption, tolerance, severity, or speed makes oral therapy unsuitable.
British Society of Gastroenterology Guidelines for the Management of Iron Deficiency Anaemia in Adults · reviewed 2026-08-26
כרטיס 91
שאלה
When may treatment proceed without prior consent in an emergency?
תשובה
When urgent treatment is needed, the patient cannot participate, no surrogate is available, and delay threatens life or serious health; document the circumstances.
Informed Consent · reviewed 2026-08-26
כרטיס 92
שאלה
What drug class or regimen fits primary adrenal insufficiency?
תשובה
Replace glucocorticoid and usually mineralocorticoid in chronic primary disease.
Primary Adrenal Insufficiency Guideline Resources · reviewed 2026-08-26
כרטיס 93
שאלה
What is the key first diagnostic step for subarachnoid hemorrhage?
תשובה
Use immediate noncontrast CT; if negative but suspicion remains, follow the time-appropriate pathway with lumbar puncture or vascular imaging.
2023 Guideline for Aneurysmal Subarachnoid Hemorrhage · reviewed 2026-08-26
כרטיס 94
שאלה
Which bedside pattern best points to celiac disease?
תשובה
Chronic diarrhea, bloating, weight loss, iron deficiency, dermatitis herpetiformis, or unexplained osteoporosis can be the clue.
ACG Clinical Guidelines: Diagnosis and Management of Celiac Disease · reviewed 2026-08-26
כרטיס 95
שאלה
In a child or adolescent, what is the key first diagnostic step for bacterial meningitis?
תשובה
Obtain blood cultures and lumbar puncture when safe; perform head imaging first only for defined risk features.
WHO Guidelines on Meningitis Diagnosis, Treatment and Care · reviewed 2026-08-26
כרטיס 96
שאלה
In a postmenopausal woman or man aged 50 or older, which diagnosis is established by a hip or vertebral fragility fracture?
תשובה
Osteoporosis. A hip or vertebral fracture from low trauma establishes osteoporosis regardless of T-score.
The clinician’s guide to prevention and treatment of osteoporosis · reviewed 2026-08-26
כרטיס 97
שאלה
What is the key first diagnostic step for preeclampsia with severe features?
תשובה
Confirm pressure correctly and assess urine protein, CBC, creatinine, liver tests, fetal status, and symptoms.
Gestational Hypertension and Preeclampsia · reviewed 2026-08-26
כרטיס 98
שאלה
In an infant aged 1–23 months, how should a clinician initially manage bronchiolitis?
תשובה
Support oxygenation and hydration; use suction selectively and assess apnea or exhaustion.
Bronchiolitis: Recommendations for Diagnosis, Monitoring and Management of Children One to 24 Months · reviewed 2026-08-26
כרטיס 99
שאלה
What is the key first diagnostic step for bipolar I mania?
תשובה
Diagnosis is clinical; assess substances, thyroid disease, medicines, psychosis, and safety.
Management of Bipolar Disorder in Adults · reviewed 2026-08-26
כרטיס 100
שאלה
How should medication be used in hypertensive emergency?
תשובה
Choose a titratable IV agent suited to the clinical syndrome; do not rapidly normalize pressure in most presentations.
2025 High Blood Pressure Guideline · reviewed 2026-08-26
כרטיס 101
שאלה
Which bedside pattern best points to obstructive sleep apnea?
תשובה
Loud snoring, witnessed apneas, gasping, daytime sleepiness, morning headache, or resistant hypertension suggests OSA.
Clinical Practice Guideline for Diagnostic Testing for Adult Obstructive Sleep Apnea · reviewed 2026-08-26
כרטיס 102
שאלה
What counseling point helps reduce harm from heart failure with reduced ejection fraction?
תשובה
Control blood pressure and coronary risk, and avoid medicines that worsen fluid retention.
2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure · reviewed 2026-08-26
כרטיס 103
שאלה
What condition should be suspected from this finding: Increasing abdominal girth, shifting dullness, edema, jaundice, or stigmata of portal hypertension suggest decompensation.
תשובה
Cirrhosis with ascites. Increasing abdominal girth, shifting dullness, edema, jaundice, or stigmata of portal hypertension suggest decompensation.
Diagnosis, Evaluation, and Management of Ascites, Spontaneous Bacterial Peritonitis and Hepatorenal Syndrome · reviewed 2026-08-26
כרטיס 104
שאלה
Which bedside pattern best points to carpal tunnel syndrome?
תשובה
Nocturnal numbness or tingling in the thumb, index, and middle fingers with thenar weakness suggests median-nerve compression.
Management of Carpal Tunnel Syndrome: Evidence-Based Clinical Practice Guideline · reviewed 2026-08-26
כרטיס 105
שאלה
In a patient with prior demyelinating events, which diagnosis fits a new focal neurologic deficit evolving over hours to days and lasting more than 24 hours?
תשובה
Multiple sclerosis relapse. A focal neurologic deficit evolving over hours to days and lasting over 24 hours, separated in time and space from prior events, suggests relapse.
Multiple Sclerosis in Adults: Management · reviewed 2026-08-26
כרטיס 106
שאלה
Which prevention or risk-reduction step is important for primary hyperparathyroidism?
תשובה
Maintain hydration and avoid unnecessary calcium-raising medicines while monitoring patients who do not have surgery.
Evaluation and Management of Primary Hyperparathyroidism: Fifth International Workshop Guidelines · reviewed 2026-08-26
כרטיס 107
שאלה
What condition should be suspected from this finding: Acute retroviral illness can cause fever, rash, pharyngitis, lymphadenopathy, or no symptoms; chronic infection may remain silent.
תשובה
HIV infection. Acute retroviral illness can cause fever, rash, pharyngitis, lymphadenopathy, or no symptoms; chronic infection may remain silent.
About HIV · reviewed 2026-08-26
כרטיס 108
שאלה
Which prevention or risk-reduction step is important for sudden sensorineural hearing loss?
תשובה
Counsel patients to seek same-day care for sudden hearing change rather than waiting for spontaneous recovery.
Clinical Practice Guideline: Sudden Hearing Loss (Update) · reviewed 2026-08-26
כרטיס 109
שאלה
For surgical decision-making, what condition should be suspected from this finding: Heavy postpartum bleeding with uterine atony, retained tissue, trauma, or coagulopathy can rapidly cause shock.
תשובה
Postpartum hemorrhage. Heavy postpartum bleeding with uterine atony, retained tissue, trauma, or coagulopathy can rapidly cause shock.
Postpartum Hemorrhage · reviewed 2026-08-26
כרטיס 110
שאלה
What is the clinician’s duty after recognizing a significant medical error that harmed a patient?
תשובה
Disclose the known facts honestly, explain the clinical impact and next care steps, express appropriate concern, and follow reporting processes.
Promoting Patient Safety · reviewed 2026-08-26
כרטיס 111
שאלה
Which diagnosis causes an acute, fluctuating disturbance of attention and awareness with disorganized thinking?
תשובה
Delirium. An acute fluctuating disturbance of attention and awareness with disorganized thinking suggests delirium.
Delirium: Prevention, Diagnosis and Management · reviewed 2026-08-26
כרטיס 112
שאלה
In a child or adolescent, what is the key first diagnostic step for nephritic syndrome?
תשובה
Use urine microscopy, protein quantification, complement and serologic testing, and biopsy for severe or unclear disease.
KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases with 2024 Chapter Updates · reviewed 2026-08-26
כרטיס 113
שאלה
Which next action matters most in uncomplicated cystitis?
תשובה
Assess for pyelonephritis, pregnancy, obstruction, or sepsis before treating as uncomplicated disease.
EAU Guidelines on Urological Infections · reviewed 2026-08-26
כרטיס 114
שאלה
What is the key first diagnostic step for acute deep-vein thrombosis?
תשובה
Use pretest probability with D-dimer or compression ultrasonography rather than symptoms alone.
ASH VTE Guidelines: Diagnosis of Venous Thromboembolism · reviewed 2026-08-26
כרטיס 115
שאלה
How should medication be used in idiopathic pulmonary fibrosis?
תשובה
Nintedanib or pirfenidone can slow functional decline; neither reverses established fibrosis.
Idiopathic Pulmonary Fibrosis: An Update and Progressive Pulmonary Fibrosis in Adults · reviewed 2026-08-26
כרטיס 116
שאלה
What diagnostic approach is most appropriate when stable chronic hypertension is suspected?
תשובה
Confirm persistent elevation with standardized office technique and out-of-office monitoring when appropriate.
2025 High Blood Pressure Guideline · reviewed 2026-08-26
כרטיס 117
שאלה
How should a clinician initially manage cirrhosis with ascites?
תשובה
Restrict sodium, assess for infection, and perform large-volume paracentesis with albumin when tense ascites causes symptoms.
Diagnosis, Evaluation, and Management of Ascites, Spontaneous Bacterial Peritonitis and Hepatorenal Syndrome · reviewed 2026-08-26
כרטיס 118
שאלה
What is the key first diagnostic step for herpes zoster?
תשובה
Clinical diagnosis is typical; PCR from a lesion is most useful when confirmation matters.
Clinical Overview of Shingles (Herpes Zoster) · reviewed 2026-08-26
כרטיס 119
שאלה
How should a clinician initially manage osteoporosis in a postmenopausal woman at high fracture risk?
תשובה
Offer pharmacologic therapy after shared decision-making, then reassess adherence and fracture risk.
Pharmacological Management of Osteoporosis in Postmenopausal Women · reviewed 2026-08-26
כרטיס 120
שאלה
Which bedside pattern best points to migraine with aura?
תשובה
Recurrent unilateral pulsating headache with nausea or sensory sensitivity, preceded by gradually spreading reversible visual or sensory symptoms, suggests migraine with aura.
ICHD-3: Migraine with Aura · reviewed 2026-08-26
כרטיס 121
שאלה
What condition should be suspected from this finding: Polyuria, polydipsia, blurred vision, recurrent infections, or an asymptomatic high-risk patient may reveal hyperglycemia.
תשובה
Type 2 diabetes mellitus. Polyuria, polydipsia, blurred vision, recurrent infections, or an asymptomatic high-risk patient may reveal hyperglycemia.
Standards of Care in Diabetes—2026 · reviewed 2026-08-26
כרטיס 122
שאלה
Which bedside pattern best points to early syphilis?
תשובה
A painless chancre or a diffuse rash involving palms and soles with generalized lymphadenopathy suggests syphilis by stage.
Primary and Secondary Syphilis: STI Treatment Guidelines · reviewed 2026-08-26
כרטיס 123
שאלה
For surgical decision-making, what condition should be suspected from this finding: Sudden painful red eye, blurred vision with halos, headache, nausea, a fixed mid-dilated pupil, and a firm globe are classic.
תשובה
Acute angle-closure glaucoma. Sudden painful red eye, blurred vision with halos, headache, nausea, a fixed mid-dilated pupil, and a firm globe are classic.
Management of Angle-Closure Glaucoma · reviewed 2026-08-26
כרטיס 124
שאלה
Which bedside pattern best points to abnormal uterine bleeding from anovulation?
תשובה
Irregular unpredictable bleeding without cyclic ovulation is common at reproductive extremes or with endocrine disruption.
Abnormal Uterine Bleeding · reviewed 2026-08-26
כרטיס 125
שאלה
How should a clinician manage a boundary-crossing gift from a patient?
תשובה
Assess its meaning, value, timing, and effect on care; decline gifts that exploit, obligate, or distort the professional relationship.
Gifts from Patients · reviewed 2026-08-26
כרטיס 126
שאלה
A clinician is considering symptomatic aortic stenosis. Which finding adds the most support?
תשובה
Exertional dyspnea, angina, or syncope with a harsh crescendo-decrescendo systolic murmur radiating to the carotids is typical.
2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease · reviewed 2026-08-26
כרטיס 127
שאלה
Which bedside pattern best points to post-traumatic stress disorder?
תשובה
Intrusion, avoidance, negative mood or cognition, and hyperarousal lasting over a month after trauma suggest PTSD.
Management of Posttraumatic Stress Disorder and Acute Stress Disorder · reviewed 2026-08-26
כרטיס 128
שאלה
In a child aged 6–11 years or an adolescent, what diagnostic approach is most appropriate when asthma is suspected?
תשובה
Demonstrate variable expiratory airflow limitation with spirometry and bronchodilator response or an accepted alternative.
2026 GINA Strategy Report · reviewed 2026-08-26
כרטיס 129
שאלה
Which prevention or risk-reduction step is important for chronic kidney disease?
תשובה
Control blood pressure, diabetes, tobacco use, and nephrotoxin exposure; vaccinate and reduce cardiovascular risk.
2024 CKD Evaluation and Management Guideline · reviewed 2026-08-26
כרטיס 130
שאלה
In a child or adolescent, how should medication be used in acute appendicitis?
תשובה
Preoperative antibiotics should cover enteric gram-negative organisms and anaerobes.
Guideline for the Diagnosis and Treatment of Appendicitis · reviewed 2026-08-26
כרטיס 131
שאלה
Which prevention or risk-reduction step is important for iron-deficiency anemia?
תשובה
Adequate dietary iron and evaluation of menstrual or gastrointestinal blood loss prevent recurrence.
British Society of Gastroenterology Guidelines for the Management of Iron Deficiency Anaemia in Adults · reviewed 2026-08-26
כרטיס 132
שאלה
Which drug class is preferred before oral therapy for knee osteoarthritis pain when topical treatment is feasible?
תשובה
Use a topical NSAID first; it provides local pain relief with less systemic exposure than an oral NSAID.
2019 ACR/Arthritis Foundation Guideline for Osteoarthritis · reviewed 2026-08-26
כרטיס 133
שאלה
A patient has this pattern: Exertional calf discomfort relieved by rest, diminished pulses, and nonhealing foot wounds suggest lower-extremity arterial disease. What is the most likely diagnosis?
תשובה
Peripheral artery disease. Exertional calf discomfort relieved by rest, diminished pulses, and nonhealing foot wounds suggest lower-extremity arterial disease.
2024 ACC/AHA Guideline for Lower Extremity Peripheral Artery Disease: Key Points · reviewed 2026-08-26
כרטיס 134
שאלה
For surgical decision-making, how should a clinician initially manage acute ischemic stroke?
תשובה
Activate a stroke pathway and evaluate immediately for IV thrombolysis and mechanical thrombectomy eligibility.
2026 Guideline for the Early Management of Patients With Acute Ischemic Stroke · reviewed 2026-08-26
כרטיס 135
שאלה
Which prevention or risk-reduction step is important for melanoma?
תשובה
Use sun protection and teach patients to report changing lesions rather than relying on routine self-treatment.
Melanoma Clinical Guidelines · reviewed 2026-08-26
כרטיס 136
שאלה
How should a clinician initially manage community-acquired pneumonia?
תשובה
Stabilize oxygenation and sepsis, then choose outpatient or inpatient care using clinical judgment and a validated severity tool.
Diagnosis and Treatment of Adults with Community-acquired Pneumonia · reviewed 2026-08-26
כרטיס 137
שאלה
Which prevention or risk-reduction step is important for ureteral stone?
תשובה
High fluid intake and stone-specific dietary changes based on metabolic evaluation reduce recurrence.
EAU Guidelines on Urolithiasis · reviewed 2026-08-26
כרטיס 138
שאלה
For surgical decision-making, how should a clinician initially manage ectopic pregnancy?
תשובה
Hemodynamic instability or suspected rupture requires emergency surgery; stable management depends on imaging, hCG, size, and follow-up reliability.
Ectopic Pregnancy · reviewed 2026-08-26
כרטיס 139
שאלה
What counseling point helps reduce harm from tension pneumothorax?
תשובה
After chest trauma or an invasive thoracic procedure, urgently reassess new dyspnea, hypotension, or unilateral breath-sound loss so tension physiology is decompressed without delay.
Thoracic Trauma WSES-AAST Guidelines · reviewed 2026-08-26
כרטיס 140
שאלה
In a child or adolescent, how should a clinician initially manage major depressive disorder?
תשובה
Assess safety first, create an urgent plan for imminent risk, and use psychotherapy, medication, or both by severity and preference.
Clinical Practice Guideline for the Assessment and Treatment of Children and Adolescents With Major and Persistent Depressive Disorders · reviewed 2026-08-26
כרטיס 141
שאלה
What should happen when a clinician’s personal belief conflicts with a requested legal service?
תשובה
Disclose the limitation without judgment, protect urgent care, provide timely information or referral, and avoid abandoning the patient.
Physician Exercise of Conscience · reviewed 2026-08-26
כרטיס 142
שאלה
For surgical decision-making, what immediate plan is appropriate for symptomatic aortic stenosis?
תשובה
Severe symptomatic aortic stenosis requires valve-replacement evaluation rather than medical therapy alone.
2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease · reviewed 2026-08-26
כרטיס 143
שאלה
What counseling point helps reduce harm from celiac disease?
תשובה
Screen appropriate first-degree relatives and correct micronutrient deficits.
ACG Clinical Guidelines: Diagnosis and Management of Celiac Disease · reviewed 2026-08-26
כרטיס 144
שאלה
How should a clinician initially manage primary hypothyroidism?
תשובה
Start replacement when indicated and recheck TSH after dose changes rather than adjusting from symptoms alone.
Guidelines for the Treatment of Hypothyroidism · reviewed 2026-08-26
כרטיס 145
שאלה
Which activity counseling can reduce carpal tunnel symptoms or slow progression?
תשובה
Modify job or recreational activities that aggravate symptoms, especially prolonged wrist flexion or extension.
Carpal Tunnel Syndrome · reviewed 2026-08-26
כרטיס 146
שאלה
How should a clinician initially manage bacterial conjunctivitis?
תשובה
Remove contact lenses and urgently assess pain, photophobia, vision loss, corneal opacity, or hyperacute discharge.
Clinical Overview of Pink Eye (Conjunctivitis) · reviewed 2026-08-26
כרטיס 147
שאלה
Which diagnosis is marked by a rising creatinine or falling urine output after illness, volume loss, nephrotoxin exposure, obstruction, or sepsis?
תשובה
Acute kidney injury. A rising creatinine or falling urine output after illness, volume loss, nephrotoxin exposure, obstruction, or sepsis indicates AKI.
KDIGO Clinical Practice Guideline for Acute Kidney Injury · reviewed 2026-08-26
כרטיס 148
שאלה
How should medication be used in bacterial brain abscess?
תשובה
Empiric therapy should cover likely streptococci, anaerobes, and staphylococci according to source, then narrow to cultures.
ESCMID Guideline on Diagnosis and Treatment of Brain Abscess in Children and Adults · reviewed 2026-08-26
כרטיס 149
שאלה
In a child or adolescent, what condition should be suspected from this finding: Isolated petechiae, bruising, or mucosal bleeding with thrombocytopenia and otherwise preserved cell lines suggests ITP.
תשובה
Immune thrombocytopenia. Isolated petechiae, bruising, or mucosal bleeding with thrombocytopenia and otherwise preserved cell lines suggests ITP.
American Society of Hematology 2019 Guidelines for Immune Thrombocytopenia · reviewed 2026-08-26
כרטיס 150
שאלה
What medication strategy is appropriate for peripheral artery disease?
תשובה
Antiplatelet and high-intensity statin therapy reduce cardiovascular risk in symptomatic disease.
2024 ACC/AHA Guideline for Lower Extremity Peripheral Artery Disease: Key Points · reviewed 2026-08-26
כרטיס 151
שאלה
A patient has this pattern: Dyspnea with reduced breath sounds, dullness to percussion, and decreased tactile fremitus suggests pleural fluid. What is the most likely diagnosis?
תשובה
Pleural effusion. Dyspnea with reduced breath sounds, dullness to percussion, and decreased tactile fremitus suggests pleural fluid.
British Thoracic Society Guideline for Pleural Disease · reviewed 2026-08-26
כרטיס 152
שאלה
How should medication be used in pulmonary tuberculosis?
תשובה
Treat drug-susceptible disease with a multidrug regimen and adherence support; tailor to susceptibility and patient factors.
Treatment for Drug-Susceptible Tuberculosis Disease · reviewed 2026-08-26
כרטיס 153
שאלה
How should medication be used in endometriosis?
תשובה
Combined hormonal contraceptives or progestins are common first-line suppressive therapies when pregnancy is not desired.
Endometriosis · reviewed 2026-08-26
כרטיס 154
שאלה
How should medication be used in panic disorder?
תשובה
SSRIs or SNRIs are preferred long-term medicines; benzodiazepines carry dependence and safety risks.
Panic Disorder: What You Need to Know · reviewed 2026-08-26
כרטיס 155
שאלה
A clinician is considering ulcerative colitis. Which finding adds the most support?
תשובה
Bloody diarrhea, urgency, tenesmus, and crampy abdominal pain with continuous colonic inflammation suggest ulcerative colitis.
Updated 2025 ACG Guidelines to Manage Adult Ulcerative Colitis Patients · reviewed 2026-08-26
כרטיס 156
שאלה
In a patient younger than 16, which diagnosis fits persistent joint swelling, limited motion, or morning stiffness after other causes are excluded?
תשובה
Juvenile idiopathic arthritis. Persistent joint swelling, limited motion, or morning stiffness beginning before age 16, after excluding other causes, suggests JIA.
2026 Juvenile Idiopathic Arthritis Guidelines · reviewed 2026-08-26
כרטיס 157
שאלה
Which bedside pattern best points to primary adrenal insufficiency?
תשובה
Weight loss, fatigue, hypotension, salt craving, hyperpigmentation, hyponatremia, and hyperkalemia suggest primary adrenal failure.
Primary Adrenal Insufficiency Guideline Resources · reviewed 2026-08-26
כרטיס 158
שאלה
When can confidential information be shared with another treating clinician without a separate HIPAA authorization?
תשובה
HIPAA generally permits disclosure for treatment, using reasonable safeguards and only information relevant to care.
Uses and Disclosures for Treatment, Payment, and Health Care Operations · reviewed 2026-08-26
כרטיס 159
שאלה
In a child aged 6 months or older, which bedside pattern best points to acute otitis media?
תשובה
A bulging tympanic membrane with acute ear pain or new otorrhea is more specific than redness alone.
Management of Acute Otitis Media in Children Six Months of Age and Older · reviewed 2026-08-26
כרטיס 160
שאלה
Which pathophysiologic process drives heart failure with reduced ejection fraction?
תשובה
Reduced contractility activates sympathetic and renin-angiotensin-aldosterone pathways that drive maladaptive remodeling.
2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure · reviewed 2026-08-26
כרטיס 161
שאלה
In a child, typically 6 months to 3 years, what immediate plan is appropriate for croup?
תשובה
Keep the child calm, give dexamethasone, and add nebulized epinephrine for moderate or severe stridor.
Acute Management of Croup in the Emergency Department · reviewed 2026-08-26
כרטיס 162
שאלה
What drug class or regimen fits cellulitis?
תשובה
Use an agent active against streptococci for nonpurulent disease; add MRSA coverage when risk or purulence warrants it.
Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections · reviewed 2026-08-26
כרטיס 163
שאלה
What is the key first diagnostic step for testicular torsion?
תשובה
Make a clinical diagnosis and obtain urgent urologic assessment; use Doppler ultrasound only if the diagnosis is uncertain and imaging will not delay exploration.
Testicular Torsion · reviewed 2026-08-26
כרטיס 164
שאלה
What counseling point helps reduce harm from Parkinson disease?
תשובה
Exercise, fall-risk reduction, medication review, and driving and swallowing assessment reduce complications.
Parkinson’s Disease in Adults · reviewed 2026-08-26
כרטיס 165
שאלה
How should a clinician initially manage hyperkalemia?
תשובה
With ECG changes or severe elevation, stabilize the myocardium, shift potassium intracellularly, and remove it from the body.
Clinical Practice Guideline: Treatment of Acute Hyperkalaemia in Adults · reviewed 2026-08-26
כרטיס 166
שאלה
What counseling point helps reduce harm from gonococcal urethritis or cervicitis?
תשובה
Condom use, routine screening by risk, and partner treatment reduce reinfection and complications.
Gonococcal Infections Among Adolescents and Adults · reviewed 2026-08-26
כרטיס 167
שאלה
Which history or examination finding most strongly supports acute pericarditis?
תשובה
Sharp pleuritic chest pain that improves when sitting forward, a friction rub, and diffuse ST elevation support pericarditis.
2025 Concise Clinical Guidance: Diagnosis and Management of Pericarditis · reviewed 2026-08-26
כרטיס 168
שאלה
What counseling point helps reduce harm from menopause vasomotor symptoms?
תשובה
Cooling strategies and avoiding individual triggers can reduce symptom burden; assess bone and cardiovascular risk separately.
The Menopause Years · reviewed 2026-08-26
כרטיס 169
שאלה
A patient has this pattern: Most chronic infections are asymptomatic; abnormal aminotransferases or risk-based screening may reveal disease. What is the most likely diagnosis?
תשובה
Chronic hepatitis C. Most chronic infections are asymptomatic; abnormal aminotransferases or risk-based screening may reveal disease.
Viral Hepatitis Clinical Care · reviewed 2026-08-26
כרטיס 170
שאלה
What counseling point helps reduce harm from alcohol withdrawal?
תשובה
Treat alcohol-use disorder, plan medically supported withdrawal for high-risk patients, and provide thiamine when nutrition is poor.
The ASAM Clinical Practice Guideline on Alcohol Withdrawal Management · reviewed 2026-08-26
כרטיס 171
שאלה
What diagnostic approach is most appropriate when acute compartment syndrome is suspected?
תשובה
Diagnosis is clinical; compartment-pressure measurement helps when the examination is unreliable or equivocal.
Management of Acute Compartment Syndrome: Evidence-Based Clinical Practice Guideline · reviewed 2026-08-26
כרטיס 172
שאלה
In a child or adolescent with sickle cell disease, which pain pattern supports an acute vaso-occlusive episode?
תשובה
Acute severe extremity, back, or bone pain that matches the patient’s typical vaso-occlusive pattern and has no alternative cause supports an acute vaso-occlusive pain episode.
ASH 2020 Guidelines for Sickle Cell Disease: Management of Acute and Chronic Pain · reviewed 2026-08-26
כרטיס 173
שאלה
What diagnostic approach is most appropriate when thyroid storm is suspected?
תשובה
Diagnosis is clinical; obtain thyroid tests and evaluate the trigger without delaying treatment.
2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis · reviewed 2026-08-26
כרטיס 174
שאלה
A clinician is considering acute respiratory distress syndrome. Which finding adds the most support?
תשובה
Acute hypoxemic respiratory failure with bilateral opacities not fully explained by cardiac failure after a known insult suggests ARDS.
An Update on Management of Adult Patients with Acute Respiratory Distress Syndrome · reviewed 2026-08-26
כרטיס 175
שאלה
How should medication be used in sudden sensorineural hearing loss?
תשובה
Offer corticosteroids within the treatment window when appropriate; intratympanic therapy is an option in selected cases.
Clinical Practice Guideline: Sudden Hearing Loss (Update) · reviewed 2026-08-26
כרטיס 176
שאלה
What is the HIPAA minimum-necessary rule?
תשובה
For many uses and disclosures, limit protected information to what is reasonably needed for the purpose; the rule does not apply in the same way to disclosures for treatment.
Minimum Necessary Requirement · reviewed 2026-08-26
כרטיס 177
שאלה
For surgical decision-making, hypotension, elevated jugular venous pressure, tachycardia, muffled heart sounds, and pulsus paradoxus indicate which diagnosis?
תשובה
Cardiac tamponade. Hypotension, elevated jugular venous pressure, tachycardia, muffled heart sounds, and pulsus paradoxus suggest tamponade physiology.
2025 Concise Clinical Guidance: Diagnosis and Management of Pericarditis · reviewed 2026-08-26
כרטיס 178
שאלה
In a child or adolescent, what diagnostic approach is most appropriate when acute appendicitis is suspected?
תשובה
Use ultrasound as the initial imaging study in many children; use CT or MRI when ultrasound is nondiagnostic and suspicion persists, according to local expertise.
Guideline for the Diagnosis and Treatment of Appendicitis · reviewed 2026-08-26
כרטיס 179
שאלה
For surgical decision-making, sudden focal weakness, facial droop, speech change, gaze deviation, neglect, or ataxia indicate which time-critical diagnosis?
תשובה
Acute ischemic stroke. Sudden focal weakness, facial droop, speech change, gaze deviation, neglect, or ataxia is stroke until proved otherwise.
2026 Guideline for the Early Management of Patients With Acute Ischemic Stroke · reviewed 2026-08-26
כרטיס 180
שאלה
A clinician is considering gout flare. Which finding adds the most support?
תשובה
Abrupt severe monoarthritis with erythema, often at the first metatarsophalangeal joint, suggests gout.
Gout · reviewed 2026-08-26
כרטיס 181
שאלה
Which diagnosis best fits new cough, fever, dyspnea, pleuritic pain, and focal crackles when an infiltrate is confirmed?
תשובה
Community-acquired pneumonia. New cough, fever, dyspnea, pleuritic pain, and focal crackles suggest pneumonia, but clinical findings alone are imperfect.
Diagnosis and Treatment of Adults with Community-acquired Pneumonia · reviewed 2026-08-26
כרטיס 182
שאלה
In a child aged 6–11 years or an adolescent, what medication strategy is appropriate for asthma?
תשובה
For children 6–11 years and adolescents, use an age-appropriate inhaled corticosteroid-containing strategy rather than short-acting beta agonist-only treatment.
2026 GINA Strategy Report · reviewed 2026-08-26
כרטיס 183
שאלה
For surgical decision-making, a patient has this pattern: Unilateral pelvic pain or bleeding in early pregnancy, especially with syncope or shoulder pain, raises concern for ectopic implantation. What is the most likely diagnosis?
תשובה
Ectopic pregnancy. Unilateral pelvic pain or bleeding in early pregnancy, especially with syncope or shoulder pain, raises concern for ectopic implantation.
Ectopic Pregnancy · reviewed 2026-08-26
כרטיס 184
שאלה
In a child or adolescent, which diagnosis requires at least two weeks of depressed mood or loss of interest with functional change and associated neurovegetative or cognitive symptoms?
תשובה
Major depressive disorder. At least two weeks of depressed mood or loss of interest with functional change and associated neurovegetative or cognitive symptoms suggests major depression.
Clinical Practice Guideline for the Assessment and Treatment of Children and Adolescents With Major and Persistent Depressive Disorders · reviewed 2026-08-26
כרטיס 185
שאלה
Which preventive measure belongs in care for atrial fibrillation?
תשובה
Address hypertension, obesity, sleep apnea, alcohol excess, and other modifiable drivers.
2023 ACC/AHA/ACCP/HRS Guideline for Atrial Fibrillation: Key Perspectives · reviewed 2026-08-26
כרטיס 186
שאלה
For surgical decision-making, what condition should be suspected from this finding: An evolving asymmetric pigmented lesion with border irregularity, color variation, or a concerning outlier pattern requires evaluation.
תשובה
Melanoma. An evolving asymmetric pigmented lesion with border irregularity, color variation, or a concerning outlier pattern requires evaluation.
Melanoma Clinical Guidelines · reviewed 2026-08-26
כרטיס 187
שאלה
Which bedside pattern best points to hyperkalemia?
תשובה
Weakness, paresthesias, bradycardia, or ECG changes can occur, but dangerous hyperkalemia may be asymptomatic.
Clinical Practice Guideline: Treatment of Acute Hyperkalaemia in Adults · reviewed 2026-08-26
כרטיס 188
שאלה
For surgical decision-making, what condition should be suspected from this finding: Sudden colicky flank pain radiating to the groin with hematuria and restlessness is typical.
תשובה
Ureteral stone. Sudden colicky flank pain radiating to the groin with hematuria and restlessness is typical.
EAU Guidelines on Urolithiasis · reviewed 2026-08-26
כרטיס 189
שאלה
In a child or adolescent, how should a clinician initially manage sickle cell vaso-occlusive crisis?
תשובה
Provide rapid individualized analgesia, assess oxygenation and hydration, and evaluate acute chest syndrome or infection.
ASH 2020 Guidelines for Sickle Cell Disease: Management of Acute and Chronic Pain · reviewed 2026-08-26
כרטיס 190
שאלה
How should medication be used in primary hyperparathyroidism?
תשובה
Cinacalcet can lower calcium when surgery is not possible; antiresorptive therapy targets low bone density.
Evaluation and Management of Primary Hyperparathyroidism: Fifth International Workshop Guidelines · reviewed 2026-08-26
כרטיס 191
שאלה
What diagnostic approach is most appropriate when acute bacterial rhinosinusitis is suspected?
תשובה
Diagnosis is clinical; routine imaging is not needed unless a complication or alternative diagnosis is suspected.
Clinical Practice Guideline: Adult Sinusitis Update · reviewed 2026-08-26
כרטיס 192
שאלה
What should a clinician do before discussing a patient in a public or semipublic area?
תשובה
Move to a private setting when practical and use reasonable safeguards so others do not overhear identifiable information.
Incidental Uses and Disclosures · reviewed 2026-08-26
כרטיס 193
שאלה
A clinician is considering Parkinson disease. Which finding adds the most support?
תשובה
Bradykinesia plus rest tremor or rigidity, with reduced arm swing and shuffling gait, supports parkinsonism.
Parkinson’s Disease in Adults · reviewed 2026-08-26
כרטיס 194
שאלה
What immediate plan is appropriate for chronic hepatitis C?
תשובה
Stage liver disease, review interactions, test for coinfections, and link every patient with active infection to curative treatment.
Viral Hepatitis Clinical Care · reviewed 2026-08-26
כרטיס 195
שאלה
A clinician is considering gonococcal urethritis or cervicitis. Which finding adds the most support?
תשובה
Purulent urethral discharge, dysuria, cervicitis, pelvic pain, or exposure may indicate gonorrhea, but infection can be asymptomatic.
Gonococcal Infections Among Adolescents and Adults · reviewed 2026-08-26
כרטיס 196
שאלה
In a child or adolescent, what immediate plan is appropriate for juvenile idiopathic arthritis?
תשובה
Refer to pediatric rheumatology early and treat to control inflammation and preserve function.
2026 Juvenile Idiopathic Arthritis Guidelines · reviewed 2026-08-26
כרטיס 197
שאלה
A clinician is considering menopause vasomotor symptoms. Which finding adds the most support?
תשובה
Hot flashes, night sweats, sleep disruption, and menstrual transition at the expected age usually identify menopausal vasomotor symptoms.
The Menopause Years · reviewed 2026-08-26
כרטיס 198
שאלה
Which diagnosis best fits this presentation: Progressive exertional dyspnea, dry cough, bibasilar fine crackles, and clubbing in an older adult suggest fibrotic interstitial disease.
תשובה
Idiopathic pulmonary fibrosis. Progressive exertional dyspnea, dry cough, bibasilar fine crackles, and clubbing in an older adult suggest fibrotic interstitial disease.
Idiopathic Pulmonary Fibrosis: An Update and Progressive Pulmonary Fibrosis in Adults · reviewed 2026-08-26
כרטיס 199
שאלה
A clinician is considering alcohol withdrawal. Which finding adds the most support?
תשובה
Tremor, autonomic hyperactivity, insomnia, nausea, anxiety, hallucinations, or seizures after reducing heavy alcohol use suggests withdrawal.
The ASAM Clinical Practice Guideline on Alcohol Withdrawal Management · reviewed 2026-08-26
כרטיס 200
שאלה
What is the priority management step for acute pericarditis?
תשובה
Assess immediately for tamponade or high-risk features that require admission.
2025 Concise Clinical Guidance: Diagnosis and Management of Pericarditis · reviewed 2026-08-26
כרטיס 201
שאלה
In complicated acute calculous cholecystitis, how should empiric antibiotics be selected?
תשובה
Base the regimen on likely biliary pathogens and local resistance patterns, with enteric gram-negative aerobes and anaerobes among the common targets.
2020 World Society of Emergency Surgery Updated Guidelines for the Diagnosis and Treatment of Acute Calculous Cholecystitis · reviewed 2026-08-26
כרטיס 202
שאלה
For surgical decision-making, what is the priority management step for pleural effusion?
תשובה
Drain a large symptomatic effusion or complicated parapneumonic collection and treat the underlying disease.
British Thoracic Society Guideline for Pleural Disease · reviewed 2026-08-26
כרטיס 203
שאלה
In acute decompensated heart failure with fluid overload, which drug class is used first to relieve congestion?
תשובה
Give an intravenous loop diuretic and adjust it to urine output, symptoms, renal function, and electrolytes.
2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure · reviewed 2026-08-26
כרטיס 204
שאלה
For surgical decision-making, what immediate plan is appropriate for subarachnoid hemorrhage?
תשובה
Stabilize, control pressure carefully, give nimodipine, and obtain urgent neurovascular treatment of the aneurysm.
2023 Guideline for Aneurysmal Subarachnoid Hemorrhage · reviewed 2026-08-26
כרטיס 205
שאלה
What medication strategy is appropriate for hip fracture?
תשובה
Use multimodal analgesia and guideline-based VTE prophylaxis around surgery.
Management of Hip Fractures in Older Adults: Evidence-Based Clinical Practice Guideline · reviewed 2026-08-26
כרטיס 206
שאלה
In a child or adolescent, what immediate plan is appropriate for bacterial meningitis?
תשובה
Give empiric antibiotics immediately; do not delay for imaging or lumbar puncture when delay is likely.
WHO Guidelines on Meningitis Diagnosis, Treatment and Care · reviewed 2026-08-26
כרטיס 207
שאלה
In a child or adolescent, which diagnosis fits hyperglycemia with dehydration, abdominal pain, vomiting, Kussmaul respirations, or altered mental status?
תשובה
Diabetic ketoacidosis. Hyperglycemia with dehydration, abdominal pain, vomiting, Kussmaul respirations, or altered mental status suggests ketoacidosis.
Standards of Care in Diabetes—2026 · reviewed 2026-08-26
כרטיס 208
שאלה
For surgical decision-making, what immediate plan is appropriate for preeclampsia with severe features?
תשובה
Stabilize the mother, prevent seizure, control persistent severe pressure, and plan delivery by gestational age and status.
Gestational Hypertension and Preeclampsia · reviewed 2026-08-26
כרטיס 209
שאלה
For surgical decision-making, new flashes, floaters, and a curtain or shadow across the visual field indicate which diagnosis?
תשובה
Retinal detachment. New flashes, floaters, and a curtain or shadow across the visual field suggest detachment.
Retinal Detachment · reviewed 2026-08-26
כרטיס 210
שאלה
What immediate plan is appropriate for bipolar I mania?
תשובה
Hospitalize when danger, grave disability, or severe psychosis requires containment; stop antidepressant monotherapy.
Management of Bipolar Disorder in Adults · reviewed 2026-08-26
כרטיס 211
שאלה
May a clinician leave appointment information in a voicemail?
תשובה
Yes, with reasonable safeguards: keep the message limited and follow any confidential communication request the patient has made.
Incidental Uses and Disclosures · reviewed 2026-08-26
כרטיס 212
שאלה
When is a loop diuretic appropriate in acute kidney injury?
תשובה
Use a loop diuretic only to manage volume overload; it does not reverse intrinsic kidney injury or improve renal recovery.
KDIGO Clinical Practice Guideline for Acute Kidney Injury · reviewed 2026-08-26
כרטיס 213
שאלה
How should a clinician initially manage plaque psoriasis?
תשובה
Assess body-surface area, special-site involvement, symptoms, and joint disease before selecting therapy.
Psoriasis Clinical Guidelines · reviewed 2026-08-26
כרטיס 214
שאלה
In a child or adolescent, how should medication be used in immune thrombocytopenia?
תשובה
Corticosteroids or IVIG are common initial treatments when therapy is needed; longer-term choices depend on response and duration.
American Society of Hematology 2019 Guidelines for Immune Thrombocytopenia · reviewed 2026-08-26
כרטיס 215
שאלה
Which test or testing sequence best evaluates suspected ventricular fibrillation cardiac arrest?
תשובה
Use rhythm analysis during high-quality CPR without delaying compressions.
2025 American Heart Association Guidelines for CPR and ECC: Adult Advanced Life Support · reviewed 2026-08-26
כרטיס 216
שאלה
Which drug class is first-line for erectile dysfunction when no contraindication such as nitrate use exists?
תשובה
Use a phosphodiesterase-5 inhibitor after reviewing cardiovascular fitness, interactions, and correct use; never combine it with nitrates.
Erectile Dysfunction Guideline · reviewed 2026-08-26
כרטיס 217
שאלה
Which pathophysiologic process drives COPD?
תשובה
Small-airway disease and emphysematous parenchymal destruction cause persistent expiratory flow limitation.
2026 GOLD Report and Pocket Guide · reviewed 2026-08-26
כרטיס 218
שאלה
Which history or examination finding most strongly supports Crohn disease?
תשובה
Chronic diarrhea, abdominal pain, weight loss, perianal disease, and skip lesions support Crohn disease.
Updated 2025 ACG Guidelines for Crohn’s Disease · reviewed 2026-08-26
כרטיס 219
שאלה
Which pathophysiologic process drives acute compartment syndrome?
תשובה
Rising pressure within a closed fascial space compromises capillary perfusion and causes muscle and nerve ischemia.
Management of Acute Compartment Syndrome: Evidence-Based Clinical Practice Guideline · reviewed 2026-08-26
כרטיס 220
שאלה
What medication strategy is appropriate for migraine with aura?
תשובה
Use an NSAID or triptan for many acute attacks; select preventive therapy around comorbidities and patient preference.
AHS Consensus Statement: Integrating New Migraine Treatments into Clinical Practice · reviewed 2026-08-26
כרטיס 221
שאלה
What clinical clue should raise suspicion for hypertensive emergency?
תשובה
Severely elevated pressure with acute neurologic, cardiac, renal, retinal, or aortic injury defines an emergency.
2025 High Blood Pressure Guideline · reviewed 2026-08-26
כרטיס 222
שאלה
What medication strategy is appropriate for early syphilis?
תשובה
Benzathine penicillin G is preferred for early syphilis; penicillin is required in pregnancy.
Primary and Secondary Syphilis: STI Treatment Guidelines · reviewed 2026-08-26
כרטיס 223
שאלה
What counseling point helps reduce harm from Cushing syndrome?
תשובה
Limit avoidable exogenous glucocorticoid exposure and taper chronic therapy safely when appropriate.
Treatment of Cushing Syndrome: An Endocrine Society Clinical Practice Guideline · reviewed 2026-08-26
כרטיס 224
שאלה
What medication strategy is appropriate for abnormal uterine bleeding from anovulation?
תשובה
Progestin or combined hormonal therapy can regulate bleeding; tranexamic acid reduces heavy bleeding in eligible patients.
Management of Acute Abnormal Uterine Bleeding in Nonpregnant Reproductive-Aged Women · reviewed 2026-08-26
כרטיס 225
שאלה
What counseling point helps reduce harm from peritonsillar abscess?
תשובה
Seek prompt care for worsening unilateral throat pain, drooling, muffled voice, trismus, or breathing difficulty so an abscess and airway risk are not missed.
Tonsillitis and Peritonsillar Abscess · reviewed 2026-08-26
כרטיס 226
שאלה
What medication strategy is appropriate for post-traumatic stress disorder?
תשובה
Sertraline, paroxetine, or venlafaxine can help; benzodiazepines are not recommended for PTSD treatment.
Management of Posttraumatic Stress Disorder and Acute Stress Disorder · reviewed 2026-08-26
כרטיס 227
שאלה
When may protected health information be disclosed to prevent a serious threat?
תשובה
HIPAA permits a good-faith disclosure consistent with law and ethical standards to someone reasonably able to prevent or lessen a serious and imminent threat.
HIPAA Disclosure to Prevent or Lessen a Serious and Imminent Threat · reviewed 2026-08-26
כרטיס 228
שאלה
In an infant aged 1–23 months, which history or examination finding most strongly supports bronchiolitis?
תשובה
An infant with viral prodrome followed by cough, wheeze or crackles, tachypnea, and feeding difficulty likely has bronchiolitis.
Bronchiolitis: Recommendations for Diagnosis, Monitoring and Management of Children One to 24 Months · reviewed 2026-08-26
כרטיס 229
שאלה
Which diagnosis causes marked edema, heavy proteinuria, hypoalbuminemia, and hyperlipidemia?
תשובה
Nephrotic syndrome. Marked edema, heavy proteinuria, hypoalbuminemia, and hyperlipidemia define a nephrotic pattern.
KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases with 2024 Chapter Updates · reviewed 2026-08-26
כרטיס 230
שאלה
Which bedside pattern best points to herpes zoster?
תשובה
A painful unilateral grouped-vesicle eruption in a dermatomal distribution is characteristic.
Clinical Overview of Shingles (Herpes Zoster) · reviewed 2026-08-26
כרטיס 231
שאלה
A patient has this pattern: Thrombocytopenia plus microangiopathic hemolytic anemia, often with neurologic, renal, or fever findings, is an emergency. What is the most likely diagnosis?
תשובה
Thrombotic thrombocytopenic purpura. Thrombocytopenia plus microangiopathic hemolytic anemia, often with neurologic, renal, or fever findings, is an emergency.
ISTH Guidelines for the Diagnosis and Treatment of Thrombotic Thrombocytopenic Purpura · reviewed 2026-08-26
כרטיס 232
שאלה
Which bedside pattern best points to testicular torsion?
תשובה
Sudden severe unilateral testicular pain with nausea or vomiting, a high-riding transverse testis, and loss of the cremasteric reflex strongly suggests torsion.
Testicular Torsion · reviewed 2026-08-26
כרטיס 233
שאלה
For surgical decision-making, which diagnosis best fits hematemesis, coffee-ground emesis, or melena with orthostasis?
תשובה
Upper gastrointestinal bleeding. Hematemesis, coffee-ground emesis, or melena with orthostasis indicates an upper gastrointestinal source until shown otherwise.
ACG Clinical Guideline: Upper Gastrointestinal and Ulcer Bleeding · reviewed 2026-08-26
כרטיס 234
שאלה
In a child or adolescent, what diagnostic approach is most appropriate when generalized tonic-clonic seizure is suspected?
תשובה
Check glucose and reversible causes; use EEG and brain imaging based on whether this is a first unprovoked event or known epilepsy.
Epilepsies in Children, Young People and Adults · reviewed 2026-08-26
כרטיס 235
שאלה
Identify the condition from this pattern: Repeated properly measured elevated readings, usually without symptoms, establish the clinical pattern.
תשובה
Stable chronic hypertension. Repeated properly measured elevated readings, usually without symptoms, establish the clinical pattern.
2025 High Blood Pressure Guideline · reviewed 2026-08-26
כרטיס 236
שאלה
What diagnostic approach is most appropriate when sepsis is suspected?
תשובה
Measure lactate, obtain cultures before antibiotics when this causes no meaningful delay, and evaluate the source.
2026 Surviving Sepsis Campaign Adult Guidelines · reviewed 2026-08-26
כרטיס 237
שאלה
For surgical decision-making, in a child with acute severe monoarticular pain, restricted passive motion, fever, or bacteremia risk, which diagnosis must be excluded urgently?
תשובה
Septic arthritis. Acute severe monoarticular pain, restricted passive motion, fever, or bacteremia risk is septic arthritis until excluded.
Guideline for Management of Septic Arthritis in Native Joints · reviewed 2026-08-26
כרטיס 238
שאלה
What diagnostic approach is most appropriate when pelvic inflammatory disease is suspected?
תשובה
Test for gonorrhea, chlamydia, HIV, and syphilis; use ultrasound when abscess or another diagnosis is possible.
Pelvic Inflammatory Disease: STI Treatment Guidelines · reviewed 2026-08-26
כרטיס 239
שאלה
Which pharmacologic approach is preferred for COPD?
תשובה
Long-acting bronchodilators are maintenance therapy; add inhaled corticosteroid for selected exacerbation-prone patients based on phenotype and eosinophils.
2026 GOLD Report and Pocket Guide · reviewed 2026-08-26
כרטיס 240
שאלה
What diagnostic approach is most appropriate when schizophrenia is suspected?
תשובה
Diagnosis is clinical with medical, neurologic, and substance evaluation for first-episode psychosis.
Management of First-Episode Psychosis and Schizophrenia · reviewed 2026-08-26
כרטיס 241
שאלה
Which next action matters most in hypertensive emergency?
תשובה
Lower pressure with monitored IV therapy at a controlled rate tailored to the injured organ.
2025 High Blood Pressure Guideline · reviewed 2026-08-26
כרטיס 242
שאלה
How should an interpreter be used for a patient with limited English proficiency?
תשובה
Use a qualified medical interpreter, speak to the patient directly, pause in short segments, and avoid relying on children or untrained family for consequential decisions.
Limited English Proficiency Guidance · reviewed 2026-08-26
כרטיס 243
שאלה
What immediate plan is appropriate for thyroid storm?
תשובה
Give a beta-blocker, block hormone synthesis, then block hormone release, add glucocorticoid, cool supportively, and treat the trigger.
2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis · reviewed 2026-08-26
כרטיס 244
שאלה
Which preventive measure belongs in care for ulcerative colitis?
תשובה
Use effective maintenance therapy and monitor symptoms together with objective inflammatory activity to reduce relapse and complications.
Updated 2025 ACG Guidelines to Manage Adult Ulcerative Colitis Patients · reviewed 2026-08-26
כרטיס 245
שאלה
What immediate plan is appropriate for acute bacterial rhinosinusitis?
תשובה
Assess orbital or intracranial red flags and arrange urgent evaluation when present.
Clinical Practice Guideline: Adult Sinusitis Update · reviewed 2026-08-26
כרטיס 246
שאלה
Which preventive measure belongs in care for gout flare?
תשובה
Weight management, limiting excess alcohol, reviewing urate-raising medicines, and long-term urate control reduce flares.
Gout · reviewed 2026-08-26
כרטיס 247
שאלה
What immediate plan is appropriate for hyponatremia due to SIADH?
תשובה
Treat severe neurologic symptoms with carefully dosed hypertonic saline and avoid overly rapid correction.
Clinical Practice Guideline on Diagnosis and Treatment of Hyponatraemia · reviewed 2026-08-26
כרטיס 248
שאלה
In a child or adolescent, which pathophysiologic process drives immune thrombocytopenia?
תשובה
Autoantibodies accelerate platelet clearance and can impair platelet production.
American Society of Hematology 2019 Guidelines for Immune Thrombocytopenia · reviewed 2026-08-26
כרטיס 249
שאלה
Which test or testing sequence best evaluates suspected COPD?
תשובה
Post-bronchodilator spirometry confirms persistent airflow obstruction.
2026 GOLD Report and Pocket Guide · reviewed 2026-08-26
כרטיס 250
שאלה
Why does atrial fibrillation produce its defining clinical pattern?
תשובה
Chaotic atrial activation eliminates coordinated atrial contraction and creates irregular AV nodal conduction.
2023 ACC/AHA/ACCP/HRS Guideline for Atrial Fibrillation: Key Perspectives · reviewed 2026-08-26
כרטיס 251
שאלה
Which pathophysiologic process drives subarachnoid hemorrhage?
תשובה
Arterial blood entering the subarachnoid space raises intracranial pressure and can trigger vasospasm.
2023 Guideline for Aneurysmal Subarachnoid Hemorrhage · reviewed 2026-08-26
כרטיס 252
שאלה
In a child or adolescent, which pathophysiologic process drives bacterial meningitis?
תשובה
Bacterial invasion of the subarachnoid space triggers intense inflammation, edema, and raised intracranial pressure.
WHO Guidelines on Meningitis Diagnosis, Treatment and Care · reviewed 2026-08-26
כרטיס 253
שאלה
Which pathophysiologic process drives preeclampsia with severe features?
תשובה
Abnormal placentation and systemic endothelial dysfunction produce vasoconstriction and multisystem injury.
Gestational Hypertension and Preeclampsia · reviewed 2026-08-26
כרטיס 254
שאלה
Which clinical feature defines bipolar I disorder?
תשובה
At least one manic episode defines bipolar I disorder; a major depressive episode is common but is not required for the diagnosis.
Management of Bipolar Disorder in Adults · reviewed 2026-08-26
כרטיס 255
שאלה
For surgical decision-making, what is the priority management step for upper gastrointestinal bleeding?
תשובה
Establish IV access, resuscitate, use a restrictive transfusion strategy for most patients, and arrange endoscopic hemostasis.
ACG Clinical Guideline: Upper Gastrointestinal and Ulcer Bleeding · reviewed 2026-08-26
כרטיס 256
שאלה
Which history or examination finding most strongly supports rheumatoid arthritis?
תשובה
Symmetric inflammatory pain and prolonged morning stiffness in MCP, PIP, or wrist joints with synovitis suggest rheumatoid arthritis.
Rheumatoid Arthritis · reviewed 2026-08-26
כרטיס 257
שאלה
What is teach-back?
תשובה
Ask the patient to explain the plan in their own words so the clinician can find and correct communication gaps without testing or blaming the patient.
Use the Teach-Back Method · reviewed 2026-08-26
כרטיס 258
שאלה
A clinician is considering primary hyperparathyroidism. Which finding adds the most support?
תשובה
Often asymptomatic hypercalcemia, nephrolithiasis, bone loss, constipation, or neurocognitive symptoms can be the clue.
Evaluation and Management of Primary Hyperparathyroidism: Fifth International Workshop Guidelines · reviewed 2026-08-26
כרטיס 259
שאלה
How can a clinician reduce avoidable harm related to aortic dissection?
תשובה
Long-term blood-pressure control and surveillance imaging reduce later aortic complications.
2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease · reviewed 2026-08-26
כרטיס 260
שאלה
A clinician is considering sudden sensorineural hearing loss. Which finding adds the most support?
תשובה
A rapid unilateral hearing decrease, often noticed on waking and sometimes with tinnitus, is an otologic emergency.
Clinical Practice Guideline: Sudden Hearing Loss (Update) · reviewed 2026-08-26
כרטיס 261
שאלה
Which preventive measure belongs in care for obstructive sleep apnea?
תשובה
Weight management, alcohol and sedative avoidance near bedtime, and treatment of nasal obstruction reduce severity.
Sleep Apnea Treatment · reviewed 2026-08-26
כרטיס 262
שאלה
In a child or adolescent, what diagnostic approach is most appropriate when atopic dermatitis is suspected?
תשובה
Diagnosis is clinical; testing is reserved for an alternative diagnosis or a specific suspected trigger.
Atopic Dermatitis Clinical Guidelines · reviewed 2026-08-26
כרטיס 263
שאלה
How should a clinician initially manage acute pyelonephritis?
תשובה
Give fluids and antibiotics, and admit patients with sepsis, inability to take oral therapy, pregnancy concerns, or obstruction.
EAU Guidelines on Urological Infections · reviewed 2026-08-26
כרטיס 264
שאלה
For surgical decision-making, which diagnosis best fits this presentation: A sudden maximal-at-onset thunderclap headache, neck stiffness, vomiting, or brief loss of consciousness is concerning.
תשובה
Subarachnoid hemorrhage. A sudden maximal-at-onset thunderclap headache, neck stiffness, vomiting, or brief loss of consciousness is concerning.
2023 Guideline for Aneurysmal Subarachnoid Hemorrhage · reviewed 2026-08-26
כרטיס 265
שאלה
What diagnostic approach is most appropriate when hyperkalemia is suspected?
תשובה
Repeat a possibly hemolyzed sample while obtaining an ECG; assess kidney function, acid-base status, and contributing medicines.
Clinical Practice Guideline: Treatment of Acute Hyperkalaemia in Adults · reviewed 2026-08-26
כרטיס 266
שאלה
In a child or adolescent, which diagnosis best fits this presentation: Fever, headache, neck stiffness, altered mental status, or a nonblanching rash should trigger urgent evaluation.
תשובה
Bacterial meningitis. Fever, headache, neck stiffness, altered mental status, or a nonblanching rash should trigger urgent evaluation.
WHO Guidelines on Meningitis Diagnosis, Treatment and Care · reviewed 2026-08-26
כרטיס 267
שאלה
What drug class or regimen fits stable chronic hypertension?
תשובה
First-line classes include thiazide-type diuretics, ACE inhibitors or ARBs, and long-acting dihydropyridine calcium-channel blockers.
2025 High Blood Pressure Guideline · reviewed 2026-08-26
כרטיס 268
שאלה
For surgical decision-making, which diagnosis best fits this presentation: New hypertension after 20 weeks with end-organ findings such as severe pressure, thrombocytopenia, liver injury, kidney injury, pulmonary edema, or neurologic symptoms suggests severe disease.
תשובה
Preeclampsia with severe features. New hypertension after 20 weeks with end-organ findings such as severe pressure, thrombocytopenia, liver injury, kidney injury, pulmonary edema, or neurologic symptoms suggests severe disease.
Gestational Hypertension and Preeclampsia · reviewed 2026-08-26
כרטיס 269
שאלה
Which pharmacologic approach is preferred for acute pancreatitis?
תשובה
Routine prophylactic antibiotics do not treat sterile pancreatitis; reserve antimicrobials for proven or strongly suspected infection.
ACG Clinical Guideline: Management of Acute Pancreatitis · reviewed 2026-08-26
כרטיס 270
שאלה
Which diagnosis best fits this presentation: At least one week of elevated or irritable mood with increased energy, decreased sleep, pressured speech, grandiosity, and risky behavior suggests mania.
תשובה
Bipolar I mania. At least one week of elevated or irritable mood with increased energy, decreased sleep, pressured speech, grandiosity, and risky behavior suggests mania.
Management of Bipolar Disorder in Adults · reviewed 2026-08-26
כרטיס 271
שאלה
For surgical decision-making, in a child or adolescent, what is the priority management step for septic arthritis?
תשובה
Drain the joint promptly and start empiric antibiotics after cultures unless the patient is unstable.
Guideline for Management of Septic Arthritis in Native Joints · reviewed 2026-08-26
כרטיס 272
שאלה
In a child or adolescent, what diagnostic approach is most appropriate when sickle cell vaso-occlusive crisis is suspected?
תשובה
Use focused labs and imaging for the suspected complication; do not require a changed hemoglobin to validate pain.
ASH 2020 Guidelines for Sickle Cell Disease: Management of Acute and Chronic Pain · reviewed 2026-08-26
כרטיס 273
שאלה
In a child or adolescent, which diagnosis causes variable wheeze, cough, chest tightness, or dyspnea that changes over time and with triggers?
תשובה
Asthma. Variable wheeze, cough, chest tightness, or dyspnea that changes over time and with triggers suggests asthma.
2026 GINA Strategy Report · reviewed 2026-08-26
כרטיס 274
שאלה
In a child or adolescent, which pathophysiologic process drives diabetic ketoacidosis?
תשובה
Absolute or marked insulin deficiency drives lipolysis, ketogenesis, osmotic diuresis, and total-body potassium loss.
Standards of Care in Diabetes—2026 · reviewed 2026-08-26
כרטיס 275
שאלה
How should a clinician respond to a patient requesting an unnecessary antibiotic?
תשובה
Acknowledge the concern, explain why the antibiotic will not help and may harm, offer a clear alternative plan, and define return precautions.
Core Elements of Outpatient Antibiotic Stewardship · reviewed 2026-08-26
כרטיס 276
שאלה
Which pathophysiologic process drives retinal detachment?
תשובה
Fluid passing through a retinal break separates neurosensory retina from the pigment epithelium.
Retinal Detachment · reviewed 2026-08-26
כרטיס 277
שאלה
Which bedside pattern best points to peripheral artery disease?
תשובה
Exertional calf discomfort relieved by rest, diminished pulses, and nonhealing foot wounds suggest lower-extremity arterial disease.
2024 ACC/AHA Guideline for Lower Extremity Peripheral Artery Disease: Key Points · reviewed 2026-08-26
כרטיס 278
שאלה
Which preventive measure belongs in care for myasthenia gravis?
תשובה
Avoid medicines that worsen neuromuscular transmission and plan carefully for infection, surgery, and pregnancy.
International Consensus Guidance for Management of Myasthenia Gravis: 2020 Update · reviewed 2026-08-26
כרטיס 279
שאלה
In a child or adolescent, which pathophysiologic process drives acute appendicitis?
תשובה
Luminal obstruction causes distention, ischemia, bacterial overgrowth, and eventual perforation.
Guideline for the Diagnosis and Treatment of Appendicitis · reviewed 2026-08-26
כרטיס 280
שאלה
Which preventive measure belongs in care for Clostridioides difficile infection?
תשובה
Isolate suspected or confirmed CDI with contact precautions, use C. difficile sporicidal agents for daily and terminal cleaning, and engage antibiotic stewardship.
Clinical Guidance for C. diff Infection Prevention in Acute Care Facilities · reviewed 2026-08-26
כרטיס 281
שאלה
After an acute ACL tear, which nonprescription medicines may be used for symptom relief when safe?
תשובה
Ibuprofen or naproxen can reduce pain and swelling; acetaminophen can reduce pain. Check comorbidities and contraindications before NSAID use.
Anterior cruciate ligament (ACL) injury - aftercare · reviewed 2026-08-26
כרטיס 282
שאלה
Which preventive measure belongs in care for shoulder dystocia?
תשובה
Team drills, clear communication, and avoiding fundal pressure reduce preventable harm.
Shoulder Dystocia · reviewed 2026-08-26
כרטיס 283
שאלה
Which next action matters most in idiopathic pulmonary fibrosis?
תשובה
Assess oxygen need, comorbidity, transplant eligibility, and goals while monitoring progression.
Idiopathic Pulmonary Fibrosis: An Update and Progressive Pulmonary Fibrosis in Adults · reviewed 2026-08-26
כרטיס 284
שאלה
In a child or adolescent, which preventive measure belongs in care for attention-deficit/hyperactivity disorder?
תשובה
Use an individualized multimodal plan with psychoeducation, parent and school interventions, and clear functional goals.
ADHD in Children and Youth: Part 2—Treatment · reviewed 2026-08-26
כרטיס 285
שאלה
Which diagnosis best fits unilateral expanding warmth, tenderness, erythema, and edema without a sharply raised border?
תשובה
Cellulitis. Unilateral expanding warmth, tenderness, erythema, and edema without a sharply raised border favor cellulitis.
Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections · reviewed 2026-08-26
כרטיס 286
שאלה
A clinician is considering hyponatremia due to SIADH. Which finding adds the most support?
תשובה
Nausea, confusion, gait change, seizure, or subtle cognitive symptoms with hypotonic euvolemic hyponatremia may reflect SIADH.
Clinical Practice Guideline on Diagnosis and Treatment of Hyponatraemia · reviewed 2026-08-26
כרטיס 287
שאלה
During a pulseless arrest, the monitor shows chaotic ventricular activity without organized QRS complexes. Which arrest rhythm is present?
תשובה
Ventricular fibrillation cardiac arrest. Sudden unresponsiveness with absent normal breathing and no pulse is cardiac arrest; the monitor may show chaotic ventricular activity.
2025 American Heart Association Guidelines for CPR and ECC: Adult Advanced Life Support · reviewed 2026-08-26
כרטיס 288
שאלה
A clinician is considering neutropenic fever. Which finding adds the most support?
תשובה
A single fever in a patient with severe chemotherapy-related neutropenia is an emergency even when examination is unrevealing.
Outpatient Management of Fever and Neutropenia in Adults Treated for Malignancy · reviewed 2026-08-26
כרטיס 289
שאלה
A patient has this pattern: Progressive weak stream, hesitancy, incomplete emptying, nocturia, and frequency suggest bladder-outlet symptoms. What is the most likely diagnosis?
תשובה
Benign prostatic hyperplasia. Progressive weak stream, hesitancy, incomplete emptying, nocturia, and frequency suggest bladder-outlet symptoms.
EAU Guidelines on the Management of Non-neurogenic Male Lower Urinary Tract Symptoms · reviewed 2026-08-26
כרטיס 290
שאלה
Which test or testing sequence best evaluates suspected primary adrenal insufficiency?
תשובה
Measure morning cortisol and ACTH, then confirm with cosyntropin testing when the patient is stable.
Primary Adrenal Insufficiency Guideline Resources · reviewed 2026-08-26
כרטיס 291
שאלה
What medication strategy is appropriate for peritonsillar abscess?
תשובה
Use antibiotics covering group A streptococci and oral anaerobes after drainage.
Tonsillitis and Peritonsillar Abscess · reviewed 2026-08-26
כרטיס 292
שאלה
What belongs in a safe handoff?
תשובה
State illness severity, active problems, recent changes, pending results, contingency plans, and who owns each next action, then allow questions.
TeamSTEPPS Communication Module · reviewed 2026-08-26
כרטיס 293
שאלה
Which history or examination finding most strongly supports myasthenia gravis?
תשובה
Fluctuating fatigable ptosis, diplopia, dysarthria, dysphagia, or proximal weakness that worsens with use suggests myasthenia.
International Consensus Guidance for Management of Myasthenia Gravis: 2020 Update · reviewed 2026-08-26
כרטיס 294
שאלה
For surgical decision-making, identify the condition from this pattern: Pain out of proportion, pain with passive stretch, tense swelling, and progressive neurologic deficits after injury are warning signs.
תשובה
Acute compartment syndrome. Pain out of proportion, pain with passive stretch, tense swelling, and progressive neurologic deficits after injury are warning signs.
Management of Acute Compartment Syndrome: Evidence-Based Clinical Practice Guideline · reviewed 2026-08-26
כרטיס 295
שאלה
Which history or examination finding most strongly supports Clostridioides difficile infection?
תשובה
New clinically significant diarrhea after antibiotics or healthcare exposure, with abdominal pain or leukocytosis, suggests C. difficile.
2021 Focused Update Guidelines on Management of Clostridioides difficile Infection in Adults · reviewed 2026-08-26
כרטיס 296
שאלה
How should a clinician confirm or characterize acute coronary syndrome?
תשובה
Obtain a 12-lead ECG within 10 minutes and measure serial high-sensitivity troponin.
2025 ACC/AHA Guideline for the Management of Patients With Acute Coronary Syndromes · reviewed 2026-08-26
כרטיס 297
שאלה
Which history or examination finding most strongly supports shoulder dystocia?
תשובה
After delivery of the head, retraction against the perineum and failure of the shoulders to deliver indicates dystocia.
Shoulder Dystocia · reviewed 2026-08-26
כרטיס 298
שאלה
In a child or adolescent, which history or examination finding most strongly supports attention-deficit/hyperactivity disorder?
תשובה
Persistent developmentally inappropriate inattention and/or hyperactivity-impulsivity in more than one setting with impairment suggests ADHD.
ADHD in Children and Youth: Part 1—Etiology, Diagnosis, and Comorbidity · reviewed 2026-08-26
כרטיס 299
שאלה
What clinical clue should raise suspicion for cirrhosis with ascites?
תשובה
Increasing abdominal girth, shifting dullness, edema, jaundice, or stigmata of portal hypertension suggest decompensation.
Diagnosis, Evaluation, and Management of Ascites, Spontaneous Bacterial Peritonitis and Hepatorenal Syndrome · reviewed 2026-08-26
כרטיס 300
שאלה
In a child, typically 6 months to 3 years, what clinical clue should raise suspicion for croup?
תשובה
Barking cough, hoarseness, and inspiratory stridor after a viral prodrome in a young child suggests croup.
Acute Management of Croup in the Emergency Department · reviewed 2026-08-26
600 כרטיסים
PANCE Flashcards: Blueprint-Aligned Diagnoses, Tests & Next Steps
ללמוד את החפיסה הזו בחינםNibomo תיפתח כדי שתוכל להתחיל ללמוד.
כרטיס 301
שאלה
How should a clinician initially manage peripheral artery disease?
תשובה
Use supervised or structured exercise; evaluate revascularization for lifestyle-limiting symptoms despite therapy or limb threat.
2024 ACC/AHA Guideline for Lower Extremity Peripheral Artery Disease: Key Points · reviewed 2026-08-26
כרטיס 302
שאלה
What drug class or regimen fits pulmonary embolism?
תשובה
Direct oral anticoagulants are preferred for many stable eligible patients; choose differently for pregnancy, severe renal disease, or specific cancer contexts.
ASH VTE Guidelines: Treatment of Deep Vein Thrombosis and Pulmonary Embolism · reviewed 2026-08-26
כרטיס 303
שאלה
For surgical decision-making, in a child or adolescent, identify the condition from this pattern: Periumbilical pain migrating to the right lower quadrant with anorexia, nausea, fever, and focal tenderness is typical.
תשובה
Acute appendicitis. Periumbilical pain migrating to the right lower quadrant with anorexia, nausea, fever, and focal tenderness is typical.
Guideline for the Diagnosis and Treatment of Appendicitis · reviewed 2026-08-26
כרטיס 304
שאלה
Which test or testing sequence best evaluates suspected hip fracture?
תשובה
Obtain hip and pelvis radiographs; MRI detects an occult fracture when suspicion remains high.
Management of Hip Fractures in Older Adults: Evidence-Based Clinical Practice Guideline · reviewed 2026-08-26
כרטיס 305
שאלה
In a child or adolescent, what is the priority management step for generalized tonic-clonic seizure?
תשובה
Protect from injury, position for airway safety, time the event, and treat as status epilepticus when it persists.
Epilepsies in Children, Young People and Adults · reviewed 2026-08-26
כרטיס 306
שאלה
Which diagnosis causes fatigue, cold intolerance, constipation, dry skin, bradycardia, and delayed reflex relaxation?
תשובה
Primary hypothyroidism. Fatigue, cold intolerance, constipation, dry skin, bradycardia, and delayed reflex relaxation support hypothyroidism.
Guidelines for the Treatment of Hypothyroidism · reviewed 2026-08-26
כרטיס 307
שאלה
What is the priority management step for sepsis?
תשובה
Start rapid resuscitation, broad empiric antimicrobials, and urgent source control.
2026 Surviving Sepsis Campaign Adult Guidelines · reviewed 2026-08-26
כרטיס 308
שאלה
Which diagnosis best fits diffuse conjunctival injection with mucopurulent discharge and eyelids stuck on waking?
תשובה
Bacterial conjunctivitis. Diffuse conjunctival injection with mucopurulent discharge and eyelids stuck on waking supports bacterial conjunctivitis.
Clinical Overview of Pink Eye (Conjunctivitis) · reviewed 2026-08-26
כרטיס 309
שאלה
What is the priority management step for pelvic inflammatory disease?
תשובה
Start empiric treatment promptly; admit for pregnancy, severe illness, abscess, surgical emergency uncertainty, or failed outpatient care.
Pelvic Inflammatory Disease: STI Treatment Guidelines · reviewed 2026-08-26
כרטיס 310
שאלה
What is closed-loop communication during an emergency?
תשובה
The receiver repeats the instruction, the sender confirms or corrects it, and completion is announced so the team shares the same state.
TeamSTEPPS Check-Back Tool · reviewed 2026-08-26
כרטיס 311
שאלה
What is the priority management step for schizophrenia?
תשובה
Assess danger, catatonia, and ability to care for self, then combine antipsychotic treatment with psychosocial support.
Management of First-Episode Psychosis and Schizophrenia · reviewed 2026-08-26
כרטיס 312
שאלה
What medication strategy is appropriate for nephrotic syndrome?
תשובה
Use renin-angiotensin system blockade to reduce proteinuria when appropriate; disease-specific immunotherapy depends on pathology.
KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases with 2024 Chapter Updates · reviewed 2026-08-26
כרטיס 313
שאלה
What immediate plan is appropriate for neutropenic fever?
תשובה
Give empiric antipseudomonal antibiotics rapidly and stratify for inpatient versus carefully selected outpatient care.
Outpatient Management of Fever and Neutropenia in Adults Treated for Malignancy · reviewed 2026-08-26
כרטיס 314
שאלה
What counseling point helps reduce harm from cellulitis?
תשובה
Treat tinea pedis, edema, skin breaks, and other portals of entry to reduce recurrence.
Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections · reviewed 2026-08-26
כרטיס 315
שאלה
A clinician is considering cardiac tamponade. Which finding adds the most support?
תשובה
Hypotension, elevated jugular venous pressure, tachycardia, muffled heart sounds, and pulsus paradoxus suggest tamponade physiology.
2025 Concise Clinical Guidance: Diagnosis and Management of Pericarditis · reviewed 2026-08-26
כרטיס 316
שאלה
What counseling point helps reduce harm from benign prostatic hyperplasia?
תשובה
Review fluid timing and medicines that worsen retention, and monitor complications.
EAU Guidelines on the Management of Non-neurogenic Male Lower Urinary Tract Symptoms · reviewed 2026-08-26
כרטיס 317
שאלה
Which diagnosis best fits progressive exertional dyspnea, chronic cough or sputum, and exposure to tobacco, biomass, or occupational irritants?
תשובה
COPD. Progressive exertional dyspnea, chronic cough or sputum, and exposure to tobacco, biomass, or occupational irritants suggest COPD.
2026 GOLD Report and Pocket Guide · reviewed 2026-08-26
כרטיס 318
שאלה
Which test or testing sequence best evaluates suspected acute cholecystitis?
תשובה
Right-upper-quadrant ultrasound is first-line; a gallbladder nuclear-medicine scan (HIDA) is an appropriate next study when ultrasound is negative or equivocal and suspicion remains high.
ACR Appropriateness Criteria® Right Upper Quadrant Pain · reviewed 2026-08-26
כרטיס 319
שאלה
In a postmenopausal woman or man aged 50 or older, what clinical clue should raise suspicion for osteoporosis?
תשובה
A fragility fracture, height loss, or kyphosis should prompt assessment for osteoporosis and vertebral fracture.
The clinician’s guide to prevention and treatment of osteoporosis · reviewed 2026-08-26
כרטיס 320
שאלה
Which pharmacologic approach is preferred for Parkinson disease?
תשובה
Levodopa provides the strongest motor benefit for many patients; dopamine agonists carry impulse-control and sleep risks.
Parkinson’s Disease in Adults · reviewed 2026-08-26
כרטיס 321
שאלה
A patient has this pattern: Pressure-like substernal pain with diaphoresis, nausea, or radiation to the arm or jaw is a classic ischemic pattern. What is the most likely diagnosis?
תשובה
Acute coronary syndrome. Pressure-like substernal pain with diaphoresis, nausea, or radiation to the arm or jaw is a classic ischemic pattern.
2025 ACC/AHA Guideline for the Management of Patients With Acute Coronary Syndromes · reviewed 2026-08-26
כרטיס 322
שאלה
Which pharmacologic approach is preferred for gonococcal urethritis or cervicitis?
תשובה
Ceftriaxone is first-line for uncomplicated infection; add chlamydia treatment if it has not been excluded.
Gonococcal Infections Among Adolescents and Adults · reviewed 2026-08-26
כרטיס 323
שאלה
In a child aged 6 months or older, which examination best evaluates suspected acute otitis media?
תשובה
Use pneumatic otoscopy to confirm middle-ear effusion and assess for a bulging tympanic membrane; tympanometry is less reliable in young infants.
Management of Acute Otitis Media in Children Six Months of Age and Older · reviewed 2026-08-26
כרטיס 324
שאלה
Which pharmacologic approach is preferred for menopause vasomotor symptoms?
תשובה
Systemic menopausal hormone therapy is most effective for eligible patients; nonhormonal options include selected SSRIs, SNRIs, gabapentin, or fezolinetant.
Hormone Therapy for Menopause · reviewed 2026-08-26
כרטיס 325
שאלה
How should a clinician handle an ambiguous verbal medication order?
תשובה
Stop and clarify the drug, dose, route, timing, and patient; read it back and do not guess.
TeamSTEPPS Communication Module · reviewed 2026-08-26
כרטיס 326
שאלה
Which pharmacologic approach is preferred for alcohol withdrawal?
תשובה
Benzodiazepines are first-line for clinically significant withdrawal; phenobarbital requires experienced protocols and monitoring.
The ASAM Clinical Practice Guideline on Alcohol Withdrawal Management · reviewed 2026-08-26
כרטיס 327
שאלה
In a child or adolescent, how should a clinician initially manage asthma?
תשובה
Assess severity during exacerbation, give repeated bronchodilator, systemic corticosteroid when indicated, oxygen, and escalate for fatigue or silent chest.
2026 GINA Strategy Report · reviewed 2026-08-26
כרטיס 328
שאלה
What medication strategy is appropriate for Cushing syndrome?
תשובה
Medical cortisol-lowering therapy can bridge or treat selected patients when definitive source control is delayed or unavailable.
Treatment of Cushing Syndrome: An Endocrine Society Clinical Practice Guideline · reviewed 2026-08-26
כרטיס 329
שאלה
What counseling point helps reduce harm from acute kidney injury?
תשובה
Avoid unnecessary nephrotoxins, adjust medicine doses, maintain perfusion, and monitor high-risk patients.
KDIGO Clinical Practice Guideline for Acute Kidney Injury · reviewed 2026-08-26
כרטיס 330
שאלה
What medication strategy is appropriate for thrombotic thrombocytopenic purpura?
תשובה
Caplacizumab is added in many acute immune TTP protocols under specialist care.
ISTH Guidelines for the Diagnosis and Treatment of Thrombotic Thrombocytopenic Purpura · reviewed 2026-08-26
כרטיס 331
שאלה
For surgical decision-making, in a child or adolescent, which next action matters most in acute appendicitis?
תשובה
Give fluids, analgesia, antibiotics, and obtain prompt surgical consultation.
Guideline for the Diagnosis and Treatment of Appendicitis · reviewed 2026-08-26
כרטיס 332
שאלה
How should medication be used in ventricular fibrillation cardiac arrest?
תשובה
Give epinephrine during the arrest algorithm and consider amiodarone or lidocaine for refractory shockable rhythms.
2025 American Heart Association Guidelines for CPR and ECC: Adult Advanced Life Support · reviewed 2026-08-26
כרטיס 333
שאלה
For surgical decision-making, which next action matters most in acute compartment syndrome?
תשובה
Remove constrictive material and obtain immediate surgical fasciotomy evaluation.
Management of Acute Compartment Syndrome: Evidence-Based Clinical Practice Guideline · reviewed 2026-08-26
כרטיס 334
שאלה
In a child or adolescent, which diagnosis fits sudden loss of consciousness with bilateral tonic then clonic movements followed by confusion?
תשובה
Generalized tonic-clonic seizure. Sudden loss of consciousness with bilateral tonic then clonic movements followed by confusion supports a generalized convulsion.
Epilepsies in Children, Young People and Adults · reviewed 2026-08-26
כרטיס 335
שאלה
How should medication be used in herpes zoster?
תשובה
Start an oral antiviral early for eligible patients, especially with severe pain, older age, or high-risk sites.
Clinical Overview of Shingles (Herpes Zoster) · reviewed 2026-08-26
כרטיס 336
שאלה
Which diagnosis is defined by suspected infection with acute organ dysfunction and may include altered mentation, hypotension, tachypnea, or poor perfusion?
תשובה
Sepsis. Suspected infection with acute organ dysfunction, altered mentation, hypotension, tachypnea, or poor perfusion suggests sepsis.
2026 Surviving Sepsis Campaign Adult Guidelines · reviewed 2026-08-26
כרטיס 337
שאלה
What medication strategy is appropriate for uncomplicated cystitis?
תשובה
Nitrofurantoin, trimethoprim-sulfamethoxazole where appropriate, or fosfomycin are common first-line options guided by patient factors and resistance.
EAU Guidelines on Urological Infections · reviewed 2026-08-26
כרטיס 338
שאלה
Which diagnosis warrants empiric treatment when lower abdominal pain occurs with cervical-motion, uterine, or adnexal tenderness in a patient at STI risk?
תשובה
Pelvic inflammatory disease. Lower abdominal pain with cervical motion, uterine, or adnexal tenderness in a patient at STI risk supports empiric PID treatment.
Pelvic Inflammatory Disease: STI Treatment Guidelines · reviewed 2026-08-26
כרטיס 339
שאלה
How should a clinician confirm or characterize pulmonary embolism?
תשובה
Use pretest probability with PERC or D-dimer when appropriate and CT pulmonary angiography for indicated stable patients.
ASH VTE Guidelines: Diagnosis of Venous Thromboembolism · reviewed 2026-08-26
כרטיס 340
שאלה
Which diagnosis requires at least six months of illness with psychosis and functional decline, including at least one month of active symptoms, after exclusions?
תשובה
Schizophrenia. At least six months of illness with psychosis and functional decline, including at least one month of active symptoms, supports schizophrenia after exclusions.
Management of First-Episode Psychosis and Schizophrenia · reviewed 2026-08-26
כרטיס 341
שאלה
Which prevention or risk-reduction step is important for infective endocarditis?
תשובה
Reserve antibiotic prophylaxis for defined high-risk cardiac conditions undergoing relevant dental procedures.
2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease · reviewed 2026-08-26
כרטיס 342
שאלה
What is the priority management step for primary adrenal insufficiency?
תשובה
Suspected adrenal crisis requires immediate glucocorticoid and isotonic fluid treatment before confirmatory results.
Primary Adrenal Insufficiency Guideline Resources · reviewed 2026-08-26
כרטיס 343
שאלה
What is the safest response to a critical test result that arrives after a patient leaves?
תשובה
Acknowledge it promptly, contact the patient or responsible team, document attempts and advice, and escalate until ownership is clear.
Quick Safety 52: Advancing Safety with Closed-loop Communication of Test Results · reviewed 2026-08-26
כרטיס 344
שאלה
In a child aged 6 months or older, what is the priority management step for acute otitis media?
תשובה
Provide analgesia; treat severe illness promptly with antibiotics and use 24–48 hours of watchful waiting only for selected mildly ill children with reliable follow-up.
Management of Acute Otitis Media in Children Six Months of Age and Older · reviewed 2026-08-26
כרטיס 345
שאלה
When antibiotic susceptibility is unknown, which empiric regimen is preferred for most treatment-naive Helicobacter pylori infection?
תשובה
Use 14-day optimized bismuth quadruple therapy: a proton-pump inhibitor, bismuth, tetracycline, and metronidazole.
ACG Clinical Guideline: Treatment of Helicobacter pylori Infection · reviewed 2026-08-26
כרטיס 346
שאלה
In a child or adolescent, which diagnosis best fits this presentation: Hematuria with dysmorphic red cells or casts, hypertension, edema, and reduced kidney function suggests glomerular inflammation.
תשובה
Nephritic syndrome. Hematuria with dysmorphic red cells or casts, hypertension, edema, and reduced kidney function suggests glomerular inflammation.
KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases with 2024 Chapter Updates · reviewed 2026-08-26
כרטיס 347
שאלה
What drug class or regimen fits carpal tunnel syndrome?
תשובה
A local corticosteroid injection can provide relief; oral medicines do not correct the compression.
Management of Carpal Tunnel Syndrome: Evidence-Based Clinical Practice Guideline · reviewed 2026-08-26
כרטיס 348
שאלה
In a child or adolescent, what counseling point helps reduce harm from immune thrombocytopenia?
תשובה
Avoid platelet-impairing medicines and counsel on bleeding precautions when counts are low.
American Society of Hematology 2019 Guidelines for Immune Thrombocytopenia · reviewed 2026-08-26
כרטיס 349
שאלה
Which test or testing sequence best evaluates suspected bacterial brain abscess?
תשובה
Contrast-enhanced MRI is preferred; obtain blood cultures and avoid lumbar puncture when mass effect is possible.
ESCMID Guideline on Diagnosis and Treatment of Brain Abscess in Children and Adults · reviewed 2026-08-26
כרטיס 350
שאלה
What physiologic disturbance underlies aortic dissection?
תשובה
An intimal tear lets blood split the aortic media, creating a false lumen.
2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease · reviewed 2026-08-26
כרטיס 351
שאלה
How can a clinician reduce avoidable harm related to acute respiratory distress syndrome?
תשובה
Use lung-protective ventilation in mechanically ventilated patients at risk for ARDS to reduce ventilator-induced injury.
An Update on Management of Adult Patients with Acute Respiratory Distress Syndrome · reviewed 2026-08-26
כרטיס 352
שאלה
Which test or testing sequence best evaluates suspected pulmonary tuberculosis?
תשובה
Obtain chest imaging and multiple respiratory specimens for nucleic-acid testing, smear, and culture with susceptibility testing.
Clinical and Laboratory Diagnosis for Tuberculosis · reviewed 2026-08-26
כרטיס 353
שאלה
Which test or testing sequence best evaluates suspected endometriosis?
תשובה
Diagnosis can be clinical with imaging for endometrioma or deep disease; laparoscopy is not mandatory before initial treatment.
Endometriosis · reviewed 2026-08-26
כרטיס 354
שאלה
Which test or testing sequence best evaluates suspected panic disorder?
תשובה
Diagnosis is clinical after considering cardiac, pulmonary, endocrine, neurologic, medication, and substance causes.
Panic Disorder: What You Need to Know · reviewed 2026-08-26
כרטיס 355
שאלה
How can a clinician reduce avoidable harm related to Crohn disease?
תשובה
Support smoking cessation and use effective maintenance therapy with objective monitoring to reduce relapse and complications.
Updated 2025 ACG Guidelines for Crohn’s Disease · reviewed 2026-08-26
כרטיס 356
שאלה
Which history or examination finding most strongly supports Cushing syndrome?
תשובה
Proximal weakness, easy bruising, facial plethora, wide violaceous striae, osteoporosis, or difficult diabetes and hypertension are discriminating clues.
Diagnosis of Cushing Syndrome: An Endocrine Society Clinical Practice Guideline · reviewed 2026-08-26
כרטיס 357
שאלה
How can a clinician reduce avoidable harm related to rheumatoid arthritis?
תשובה
Keep indicated vaccines current and coordinate timing with immunosuppressive therapy to reduce preventable infection risk.
2022 American College of Rheumatology Guideline for Vaccinations in Patients With Rheumatic and Musculoskeletal Diseases · reviewed 2026-08-26
כרטיס 358
שאלה
Which history or examination finding most strongly supports peritonsillar abscess?
תשובה
Severe unilateral sore throat, muffled voice, drooling, trismus, and uvular deviation suggest a peritonsillar collection.
Tonsillitis and Peritonsillar Abscess · reviewed 2026-08-26
כרטיס 359
שאלה
When should a safety event or near miss be reported?
תשובה
Report it through the local safety system promptly, including near misses, so hazards can be corrected without waiting for patient harm.
Reporting Patient Safety Events · reviewed 2026-08-26
כרטיס 360
שאלה
For surgical decision-making, what immediate plan is appropriate for cardiac tamponade?
תשובה
Urgent pericardial drainage is the definitive step when tamponade causes hemodynamic compromise.
2025 Concise Clinical Guidance: Diagnosis and Management of Pericarditis · reviewed 2026-08-26
כרטיס 361
שאלה
Which bedside pattern best points to pleural effusion?
תשובה
Dyspnea with reduced breath sounds, dullness to percussion, and decreased tactile fremitus suggests pleural fluid.
British Thoracic Society Guideline for Pleural Disease · reviewed 2026-08-26
כרטיס 362
שאלה
For surgical decision-making, what immediate plan is appropriate for melanoma?
תשובה
Prompt complete diagnostic excision and staging guide definitive surgical management.
Melanoma Clinical Guidelines · reviewed 2026-08-26
כרטיס 363
שאלה
A clinician is considering uncomplicated cystitis. Which finding adds the most support?
תשובה
Dysuria and frequency without vaginal symptoms strongly support lower urinary infection in an appropriate patient.
EAU Guidelines on Urological Infections · reviewed 2026-08-26
כרטיס 364
שאלה
In a child or adolescent, which clinical sequence defines a generalized tonic-clonic seizure?
תשובה
Loss of consciousness with bilateral tonic stiffening followed by clonic jerking and a postictal period defines the typical sequence.
Epilepsies in Children, Young People and Adults · reviewed 2026-08-26
כרטיס 365
שאלה
What is the priority management step for chronic kidney disease?
תשובה
Identify cause, quantify progression risk, treat complications, and refer for high-risk features or advanced disease.
2024 CKD Evaluation and Management Guideline · reviewed 2026-08-26
כרטיס 366
שאלה
Why does sepsis produce its defining clinical pattern?
תשובה
A dysregulated host response causes endothelial injury, vasodilation, capillary leak, and organ dysfunction.
2026 Surviving Sepsis Campaign Adult Guidelines · reviewed 2026-08-26
כרטיס 367
שאלה
Which history or examination finding most strongly supports stable chronic hypertension?
תשובה
Repeated properly measured elevated readings, usually without symptoms, establish the clinical pattern.
2025 High Blood Pressure Guideline · reviewed 2026-08-26
כרטיס 368
שאלה
Why does pelvic inflammatory disease produce its defining clinical pattern?
תשובה
Ascending polymicrobial infection inflames endometrium and tubes, causing scarring and future ectopic or infertility risk.
Pelvic Inflammatory Disease: STI Treatment Guidelines · reviewed 2026-08-26
כרטיס 369
שאלה
Which bedside pattern best points to chronic hepatitis C?
תשובה
Most chronic infections are asymptomatic; abnormal aminotransferases or risk-based screening may reveal disease.
Viral Hepatitis Clinical Care · reviewed 2026-08-26
כרטיס 370
שאלה
Which symptom domains should a clinician assess in schizophrenia?
תשובה
Assess positive, negative, cognitive, and mood symptoms together with substance use, functioning, and safety.
Management of First-Episode Psychosis and Schizophrenia · reviewed 2026-08-26
כרטיס 371
שאלה
For surgical decision-making, an older adult after a fall has groin pain, cannot bear weight, and holds a shortened, externally rotated leg. Which diagnosis is most likely?
תשובה
Hip fracture. An older adult after a fall with groin pain, inability to bear weight, and a shortened externally rotated leg likely has a hip fracture.
Management of Hip Fractures in Older Adults: Evidence-Based Clinical Practice Guideline · reviewed 2026-08-26
כרטיס 372
שאלה
In pulmonary embolism with hemodynamic compromise and no prohibitive bleeding risk, which drug class should be considered for reperfusion?
תשובה
Use systemic thrombolytic therapy followed by anticoagulation; weigh the immediate bleeding risk and activate an advanced-reperfusion pathway.
ASH 2020 Guidelines for Treatment of Deep Vein Thrombosis and Pulmonary Embolism · reviewed 2026-08-26
כרטיס 373
שאלה
Which diagnosis best fits this presentation: Unilateral leg swelling, pain, warmth, and risk from immobility, surgery, cancer, estrogen, or prior VTE raise suspicion.
תשובה
Acute deep-vein thrombosis. Unilateral leg swelling, pain, warmth, and risk from immobility, surgery, cancer, estrogen, or prior VTE raise suspicion.
ASH VTE Guidelines: Diagnosis of Venous Thromboembolism · reviewed 2026-08-26
כרטיס 374
שאלה
Which preventive measure belongs in care for type 2 diabetes mellitus?
תשובה
Weight-supportive nutrition, physical activity, tobacco avoidance, and cardiometabolic risk control prevent complications.
Standards of Care in Diabetes—2026 · reviewed 2026-08-26
כרטיס 375
שאלה
What is the first response when a colleague appears impaired while providing care?
תשובה
Protect patients immediately, remove the colleague from unsafe duties through the proper chain, and activate confidential professional-assistance procedures.
Physician Responsibilities to Colleagues with Illness, Disability or Impairment · reviewed 2026-08-26
כרטיס 376
שאלה
Which preventive measure belongs in care for acute angle-closure glaucoma?
תשובה
Definitive treatment of the fellow narrow-angle eye helps prevent a second attack.
Management of Angle-Closure Glaucoma · reviewed 2026-08-26
כרטיס 377
שאלה
Exertional dyspnea, orthopnea, edema, elevated jugular venous pressure, an S3, and an echocardiographic LVEF of 35% indicate which heart-failure phenotype?
תשובה
Heart failure with reduced ejection fraction (HFrEF). The congestion findings establish heart failure, and an LVEF of 40% or less identifies the reduced-EF phenotype.
2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure · reviewed 2026-08-26
כרטיס 378
שאלה
What clinical clue should raise suspicion for multiple sclerosis relapse?
תשובה
A focal neurologic deficit evolving over hours to days and lasting over 24 hours, separated in time and space from prior events, suggests relapse.
Multiple Sclerosis in Adults: Management · reviewed 2026-08-26
כרטיס 379
שאלה
For surgical decision-making, which diagnosis best fits persistent right-upper-quadrant pain or tenderness, fever, leukocytosis, and a positive Murphy sign?
תשובה
Acute calculous cholecystitis. The combined clinical and inflammatory findings support the diagnosis; confirm it with imaging.
2020 World Society of Emergency Surgery Updated Guidelines for the Diagnosis and Treatment of Acute Calculous Cholecystitis · reviewed 2026-08-26
כרטיס 380
שאלה
What clinical clue should raise suspicion for HIV infection?
תשובה
Acute retroviral illness can cause fever, rash, pharyngitis, lymphadenopathy, or no symptoms; chronic infection may remain silent.
About HIV · reviewed 2026-08-26
כרטיס 381
שאלה
Why does hip fracture produce its defining clinical pattern?
תשובה
Osteoporotic bone can fail under low-energy load, and immobility rapidly adds medical risk.
Management of Hip Fractures in Older Adults: Evidence-Based Clinical Practice Guideline · reviewed 2026-08-26
כרטיס 382
שאלה
What clinical clue should raise suspicion for postpartum hemorrhage?
תשובה
Heavy postpartum bleeding with uterine atony, retained tissue, trauma, or coagulopathy can rapidly cause shock.
Postpartum Hemorrhage · reviewed 2026-08-26
כרטיס 383
שאלה
Why does pulmonary embolism produce its defining clinical pattern?
תשובה
Pulmonary embolism is venous thromboembolism obstructing the pulmonary arteries, which increases right-ventricular afterload.
ASH VTE Guidelines: Treatment of Deep Vein Thrombosis and Pulmonary Embolism · reviewed 2026-08-26
כרטיס 384
שאלה
What clinical clue should raise suspicion for delirium?
תשובה
An acute fluctuating disturbance of attention and awareness with disorganized thinking suggests delirium.
Delirium: Prevention, Diagnosis and Management · reviewed 2026-08-26
כרטיס 385
שאלה
For surgical decision-making, what immediate plan is appropriate for ureteral stone?
תשובה
Provide analgesia, check for infection and kidney injury, and decompress urgently when obstruction is infected.
EAU Guidelines on Urolithiasis · reviewed 2026-08-26
כרטיס 386
שאלה
What is the key first diagnostic step for heart failure with reduced ejection fraction?
תשובה
Transthoracic echocardiography defines ejection fraction and structural disease.
2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure · reviewed 2026-08-26
כרטיס 387
שאלה
In a child or adolescent, a clinician is considering atopic dermatitis. Which finding adds the most support?
תשובה
Chronic pruritic eczematous patches with age-dependent flexural or facial distribution and a relapsing course are typical.
Atopic Dermatitis Clinical Guidelines · reviewed 2026-08-26
כרטיס 388
שאלה
Which diagnosis causes fever, marked tachycardia, agitation or delirium, gastrointestinal symptoms, and heart failure in a patient with thyrotoxicosis?
תשובה
Thyroid storm. Fever, marked tachycardia, agitation or delirium, gastrointestinal symptoms, and heart failure in thyrotoxicosis suggest storm.
2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis · reviewed 2026-08-26
כרטיס 389
שאלה
Which history or examination finding most strongly supports chronic kidney disease?
תשובה
CKD may be silent; edema, pruritus, anemia, hypertension, or abnormal urine testing often appears later.
2024 CKD Evaluation and Management Guideline · reviewed 2026-08-26
כרטיס 390
שאלה
Identify the condition from this pattern: Persistent symptoms beyond 10 days, severe fever with purulent drainage, or worsening after initial improvement are patterns that support bacterial disease.
תשובה
Acute bacterial rhinosinusitis. Persistent symptoms beyond 10 days, severe fever with purulent drainage, or worsening after initial improvement are patterns that support bacterial disease.
Clinical Practice Guideline: Adult Sinusitis Update · reviewed 2026-08-26
כרטיס 391
שאלה
Which history or examination finding most strongly supports iron-deficiency anemia?
תשובה
Fatigue, pica, restless legs, koilonychia, or chronic blood loss can accompany microcytic anemia.
British Society of Gastroenterology Guidelines for the Management of Iron Deficiency Anaemia in Adults · reviewed 2026-08-26
כרטיס 392
שאלה
How should a clinician respond to a patient’s prejudiced request or discriminatory behavior?
תשובה
Address the behavior directly, explore its reasons, set limits that protect staff and other patients, and do not accommodate invidious discrimination; urgent care still takes priority.
Discrimination and Disruptive Behavior by Patients · reviewed 2026-08-26
כרטיס 393
שאלה
For surgical decision-making, which next action matters most in bacterial brain abscess?
תשובה
Start IV antibiotics and obtain urgent neurosurgical consultation for aspiration or drainage when indicated.
ESCMID Guideline on Diagnosis and Treatment of Brain Abscess in Children and Adults · reviewed 2026-08-26
כרטיס 394
שאלה
How should a clinician confirm or characterize acute pancreatitis?
תשובה
Diagnosis requires two of three: characteristic pain, lipase or amylase at least three times normal, or compatible imaging.
ACG Clinical Guideline: Management of Acute Pancreatitis · reviewed 2026-08-26
כרטיס 395
שאלה
Which next action matters most in pulmonary tuberculosis?
תשובה
Isolate suspected contagious disease and coordinate promptly with public health.
Tuberculosis Infection Control · reviewed 2026-08-26
כרטיס 396
שאלה
How should a clinician confirm or characterize anterior cruciate ligament tear?
תשובה
MRI confirms associated soft-tissue injury when it will guide management; radiographs assess fracture.
Management of Anterior Cruciate Ligament Injuries: Evidence-Based Clinical Practice Guideline · reviewed 2026-08-26
כרטיס 397
שאלה
For surgical decision-making, which next action matters most in endometriosis?
תשובה
Offer empiric symptom treatment or surgery based on severity, fertility goals, masses, and response.
Endometriosis · reviewed 2026-08-26
כרטיס 398
שאלה
A patient has this pattern: Sudden dyspnea, pleuritic pain, tachycardia, hypoxemia, hemoptysis, or syncope with VTE risk raises suspicion. What is the most likely diagnosis?
תשובה
Pulmonary embolism. Sudden dyspnea, pleuritic pain, tachycardia, hypoxemia, hemoptysis, or syncope with VTE risk raises suspicion.
ASH VTE Guidelines: Diagnosis of Venous Thromboembolism · reviewed 2026-08-26
כרטיס 399
שאלה
Which next action matters most in panic disorder?
תשובה
During an attack, ensure safety and exclude an emergency; for ongoing disorder, offer cognitive behavioral therapy and/or medication.
Panic Disorder: What You Need to Know · reviewed 2026-08-26
כרטיס 400
שאלה
What medication strategy is appropriate for acute coronary syndrome?
תשובה
Use dual antiplatelet therapy after ACS when indicated, balancing ischemic benefit against bleeding risk.
2025 ACC/AHA Guideline for the Management of Patients With Acute Coronary Syndromes · reviewed 2026-08-26
כרטיס 401
שאלה
What immediate plan is appropriate for COPD?
תשובה
For an exacerbation, increase short-acting bronchodilation, use systemic steroids, add antibiotics when indicated, and support ventilation.
2026 GOLD Report and Pocket Guide · reviewed 2026-08-26
כרטיס 402
שאלה
In a child or adolescent, which bedside pattern best points to juvenile idiopathic arthritis?
תשובה
Persistent joint swelling, limited motion, or morning stiffness beginning before age 16, after excluding other causes, suggests JIA.
2026 Juvenile Idiopathic Arthritis Guidelines · reviewed 2026-08-26
כרטיס 403
שאלה
What is the priority management step for stable chronic hypertension?
תשובה
Estimate cardiovascular risk, assess target-organ damage, and set an individualized treatment plan.
2025 High Blood Pressure Guideline · reviewed 2026-08-26
כרטיס 404
שאלה
What drug class or regimen fits myasthenia gravis?
תשובה
Pyridostigmine treats symptoms; corticosteroid or other immunotherapy controls autoimmune activity.
International Consensus Guidance for Management of Myasthenia Gravis: 2020 Update · reviewed 2026-08-26
כרטיס 405
שאלה
For surgical decision-making, how should a fit patient with acute calculous cholecystitis be managed initially?
תשובה
Give fluids and analgesia, prescribe antibiotics when indicated, and arrange early laparoscopic cholecystectomy as soon as possible.
2020 World Society of Emergency Surgery Updated Guidelines for the Diagnosis and Treatment of Acute Calculous Cholecystitis · reviewed 2026-08-26
כרטיס 406
שאלה
What drug class or regimen fits Clostridioides difficile infection?
תשובה
Oral fidaxomicin is preferred for many initial episodes; oral vancomycin remains an accepted alternative.
2021 Focused Update Guidelines on Management of Clostridioides difficile Infection in Adults · reviewed 2026-08-26
כרטיס 407
שאלה
How should a clinician confirm or characterize primary hyperparathyroidism?
תשובה
Confirm elevated albumin-corrected or ionized calcium with an inappropriately high PTH; assess kidneys and bone.
Evaluation and Management of Primary Hyperparathyroidism: Fifth International Workshop Guidelines · reviewed 2026-08-26
כרטיס 408
שאלה
Which medication prevents seizures in preeclampsia with severe features?
תשובה
Use magnesium sulfate for seizure prophylaxis while controlling severe hypertension and planning delivery according to maternal and fetal status.
Gestational Hypertension and Preeclampsia · reviewed 2026-08-26
כרטיס 409
שאלה
What is shared decision-making?
תשובה
The clinician presents reasonable options and evidence, elicits the patient’s goals and tradeoffs, and reaches a choice together when more than one path is reasonable.
The SHARE Approach · reviewed 2026-08-26
כרטיס 410
שאלה
In a child aged 6 years or older or an adolescent, what drug class or regimen fits attention-deficit/hyperactivity disorder?
תשובה
Extended-release stimulants are first-line medication for most children and adolescents when combined with nonpharmacologic care and monitored for benefit and adverse effects.
ADHD in Children and Youth: Part 2—Treatment · reviewed 2026-08-26
כרטיס 411
שאלה
What is the priority management step for iron-deficiency anemia?
תשובה
Identify and control bleeding, then replace iron; investigate occult gastrointestinal loss when appropriate.
British Society of Gastroenterology Guidelines for the Management of Iron Deficiency Anaemia in Adults · reviewed 2026-08-26
כרטיס 412
שאלה
Which pharmacologic approach is preferred for acute angle-closure glaucoma?
תשובה
Use pressure-lowering topical agents plus systemic acetazolamide when appropriate; pilocarpine is added after pressure begins to fall.
Management of Angle-Closure Glaucoma · reviewed 2026-08-26
כרטיס 413
שאלה
Which diagnosis best fits this presentation: A painful unilateral grouped-vesicle eruption in a dermatomal distribution is characteristic.
תשובה
Herpes zoster. A painful unilateral grouped-vesicle eruption in a dermatomal distribution is characteristic.
Clinical Overview of Shingles (Herpes Zoster) · reviewed 2026-08-26
כרטיס 414
שאלה
In a child or adolescent, which pharmacologic approach is preferred for nephritic syndrome?
תשובה
Immunosuppression is disease-specific and should follow a supported diagnosis rather than empiric routine use.
KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases with 2024 Chapter Updates · reviewed 2026-08-26
כרטיס 415
שאלה
What counseling point helps reduce harm from symptomatic aortic stenosis?
תשובה
Teach patients to report exertional dyspnea, angina, presyncope, or syncope promptly; new symptoms require timely reassessment, and severe symptomatic AS warrants valve-team evaluation rather than surveillance alone.
2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease · reviewed 2026-08-26
כרטיס 416
שאלה
For surgical decision-making, which diagnosis best fits this presentation: Abrupt severe unilateral scrotal pain, a high-riding transverse testis, nausea, and an absent cremasteric reflex are concerning.
תשובה
Testicular torsion. Sudden severe unilateral pain with nausea or vomiting, a high-riding transverse testis, and loss of the cremasteric reflex is the classic pattern.
Testicular Torsion · reviewed 2026-08-26
כרטיס 417
שאלה
A clinician is considering idiopathic pulmonary fibrosis. Which finding adds the most support?
תשובה
Progressive exertional dyspnea, dry cough, bibasilar fine crackles, and clubbing in an older adult suggest fibrotic interstitial disease.
Idiopathic Pulmonary Fibrosis: An Update and Progressive Pulmonary Fibrosis in Adults · reviewed 2026-08-26
כרטיס 418
שאלה
How should medication be used in ulcerative colitis?
תשובה
Use 5-aminosalicylates for many mild-to-moderate cases; advanced therapy is selected by severity and prior response.
Updated 2025 ACG Guidelines to Manage Adult Ulcerative Colitis Patients · reviewed 2026-08-26
כרטיס 419
שאלה
For surgical decision-making, how should a clinician initially manage hip fracture?
תשובה
Provide analgesia, optimize medical issues, and arrange timely operative management for most displaced fractures.
Management of Hip Fractures in Older Adults: Evidence-Based Clinical Practice Guideline · reviewed 2026-08-26
כרטיס 420
שאלה
For surgical decision-making, what condition should be suspected from this finding: Headache, fever, focal deficit, seizure, or signs of raised intracranial pressure after sinus, ear, dental, or bloodstream infection raise suspicion.
תשובה
Bacterial brain abscess. Headache, fever, focal deficit, seizure, or signs of raised intracranial pressure after sinus, ear, dental, or bloodstream infection raise suspicion.
ESCMID Guideline on Diagnosis and Treatment of Brain Abscess in Children and Adults · reviewed 2026-08-26
כרטיס 421
שאלה
What clinical clue should raise suspicion for ventricular fibrillation cardiac arrest?
תשובה
Sudden unresponsiveness with absent normal breathing and no pulse is cardiac arrest; the monitor may show chaotic ventricular activity.
2025 American Heart Association Guidelines for CPR and ECC: Adult Advanced Life Support · reviewed 2026-08-26
כרטיס 422
שאלה
What condition should be suspected from this finding: Chronic cough, fever, night sweats, weight loss, hemoptysis, or epidemiologic exposure raises concern.
תשובה
Pulmonary tuberculosis. Chronic cough, fever, night sweats, weight loss, hemoptysis, or epidemiologic exposure raises concern.
Clinical Overview of Tuberculosis Disease · reviewed 2026-08-26
כרטיס 423
שאלה
Which pharmacologic approach is preferred for type 2 diabetes mellitus?
תשובה
Choose glucose-lowering therapy around comorbid ASCVD, heart failure, CKD, weight goals, hypoglycemia risk, and patient priorities; metformin remains appropriate for many.
Standards of Care in Diabetes—2026 · reviewed 2026-08-26
כרטיס 424
שאלה
For surgical decision-making, which diagnosis best fits cyclic pelvic pain, dysmenorrhea, deep dyspareunia, painful defecation, or infertility?
תשובה
Endometriosis. Cyclic pelvic pain, dysmenorrhea, deep dyspareunia, painful defecation, or infertility suggests endometriosis.
Endometriosis · reviewed 2026-08-26
כרטיס 425
שאלה
How should a clinician confirm or characterize sudden sensorineural hearing loss?
תשובה
Differentiate sensorineural from conductive loss with bedside testing and urgent audiometry.
Clinical Practice Guideline: Sudden Hearing Loss (Update) · reviewed 2026-08-26
כרטיס 426
שאלה
Which diagnosis requires recurrent unexpected panic attacks plus persistent worry or maladaptive avoidance for at least one month?
תשובה
Panic disorder. Recurrent unexpected panic attacks plus persistent worry or maladaptive avoidance for at least a month suggests panic disorder.
Panic Disorder: What You Need to Know · reviewed 2026-08-26
כרטיס 427
שאלה
How should uncertainty be communicated?
תשובה
Name what is known and unknown, explain the leading possibilities and why, state the plan to reduce uncertainty, and give specific follow-up or return precautions.
Why Does Clinical Uncertainty Matter? · reviewed 2026-08-26
כרטיס 428
שאלה
Which medication is FDA-approved for moderate-to-severe obstructive sleep apnea in adults with obesity?
תשובה
Tirzepatide is approved for adults with obesity and moderate-to-severe obstructive sleep apnea, used with a reduced-calorie diet and increased physical activity.
FDA Approves First Medication for Obstructive Sleep Apnea · reviewed 2026-08-26
כרטיס 429
שאלה
Which pathophysiologic process drives acute kidney injury?
תשובה
Abrupt loss of filtration disturbs volume, electrolytes, acid-base balance, and toxin clearance.
KDIGO Clinical Practice Guideline for Acute Kidney Injury · reviewed 2026-08-26
כרטיס 430
שאלה
Which pharmacologic approach is preferred for acute deep-vein thrombosis?
תשובה
A direct oral anticoagulant is preferred for many eligible patients; selection changes with pregnancy, cancer, renal function, and antiphospholipid syndrome.
ASH VTE Guidelines: Treatment of Deep Vein Thrombosis and Pulmonary Embolism · reviewed 2026-08-26
כרטיס 431
שאלה
A clinician is considering upper gastrointestinal bleeding. Which finding adds the most support?
תשובה
Hematemesis, coffee-ground emesis, or melena with orthostasis indicates an upper gastrointestinal source until shown otherwise.
ACG Clinical Guideline: Upper Gastrointestinal and Ulcer Bleeding · reviewed 2026-08-26
כרטיס 432
שאלה
How should medication be used in gout flare?
תשובה
Use an NSAID, colchicine, or glucocorticoid based on comorbidity and timing; allopurinol is preferred long-term urate lowering for most.
2020 American College of Rheumatology Guideline for the Management of Gout · reviewed 2026-08-26
כרטיס 433
שאלה
Which diagnosis best fits an irregularly irregular pulse with palpitations, fatigue, or dyspnea?
תשובה
Atrial fibrillation. An irregularly irregular pulse with palpitations, fatigue, or dyspnea suggests atrial fibrillation.
2023 ACC/AHA/ACCP/HRS Guideline for Atrial Fibrillation: Key Perspectives · reviewed 2026-08-26
כרטיס 434
שאלה
Which treatment should not be offered solely to treat multiple sclerosis?
תשובה
Do not offer vitamin D solely to treat multiple sclerosis.
Multiple Sclerosis in Adults: Management · reviewed 2026-08-26
כרטיס 435
שאלה
Which pathophysiologic process drives plaque psoriasis?
תשובה
IL-23 and Th17 pathway activation drives accelerated keratinocyte turnover.
Psoriasis Clinical Guidelines · reviewed 2026-08-26
כרטיס 436
שאלה
How can a clinician reduce avoidable harm related to HIV infection?
תשובה
PrEP, condoms, sterile injection equipment, perinatal treatment, and sustained viral suppression prevent transmission.
Preventing HIV · reviewed 2026-08-26
כרטיס 437
שאלה
Which pathophysiologic process drives acute pyelonephritis?
תשובה
Ascending infection reaches the renal pelvis and parenchyma, producing systemic illness.
EAU Guidelines on Urological Infections · reviewed 2026-08-26
כרטיס 438
שאלה
How can a clinician reduce avoidable harm related to postpartum hemorrhage?
תשובה
Antenatal anemia treatment, active management of the third stage, and hemorrhage protocols reduce morbidity.
Postpartum Hemorrhage · reviewed 2026-08-26
כרטיס 439
שאלה
What is the key first diagnostic step for tension pneumothorax?
תשובה
Diagnosis is clinical in an unstable patient; bedside ultrasound can support it but imaging must not delay decompression.
Thoracic Trauma WSES-AAST Guidelines · reviewed 2026-08-26
כרטיס 440
שאלה
How can a clinician reduce avoidable harm related to delirium?
תשובה
Orientation, mobility, sleep protection, hearing and vision aids, hydration, and medication review reduce hospital delirium.
Delirium: Prevention, Diagnosis and Management · reviewed 2026-08-26
כרטיס 441
שאלה
What core mechanism explains infective endocarditis?
תשובה
Microbial adherence to damaged endocardium or prosthetic material produces infected vegetations.
2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease · reviewed 2026-08-26
כרטיס 442
שאלה
For surgical decision-making, which next action matters most in primary hyperparathyroidism?
תשובה
Refer for parathyroidectomy when symptomatic or when guideline thresholds for calcium, kidney, bone, or age are met.
Evaluation and Management of Primary Hyperparathyroidism: Fifth International Workshop Guidelines · reviewed 2026-08-26
כרטיס 443
שאלה
What makes a useful return precaution?
תשובה
It names concrete symptoms or changes, states how urgently to act, and tells the patient where to seek help.
IDEAL Discharge Planning Overview, Process, and Checklist · reviewed 2026-08-26
כרטיס 444
שאלה
Which next action matters most in sudden sensorineural hearing loss?
תשובה
Arrange urgent otolaryngology evaluation and assess for retrocochlear pathology.
Clinical Practice Guideline: Sudden Hearing Loss (Update) · reviewed 2026-08-26
כרטיס 445
שאלה
A patient has this pattern: Severe persistent epigastric pain radiating to the back with nausea and vomiting is typical. What is the most likely diagnosis?
תשובה
Acute pancreatitis. Severe persistent epigastric pain radiating to the back with nausea and vomiting is typical.
ACG Clinical Guideline: Management of Acute Pancreatitis · reviewed 2026-08-26
כרטיס 446
שאלה
For surgical decision-making, a noncontact pivot causes an audible pop, immediate swelling, instability, and a positive Lachman test. What is the most likely diagnosis?
תשובה
Anterior cruciate ligament tear. A noncontact pivot, audible pop, immediate swelling, and instability with a positive Lachman test suggest an ACL tear.
Management of Anterior Cruciate Ligament Injuries: Evidence-Based Clinical Practice Guideline · reviewed 2026-08-26
כרטיס 447
שאלה
Which bedside pattern best points to acute ischemic stroke?
תשובה
Sudden focal weakness, facial droop, speech change, gaze deviation, neglect, or ataxia is stroke until proved otherwise.
2026 Guideline for the Early Management of Patients With Acute Ischemic Stroke · reviewed 2026-08-26
כרטיס 448
שאלה
Which electrolyte disorder may cause weakness, paresthesias, bradycardia, or ECG changes but can be dangerous even without symptoms?
תשובה
Hyperkalemia. Weakness, paresthesias, bradycardia, or ECG changes can occur, but dangerous hyperkalemia may be asymptomatic.
Clinical Practice Guideline: Treatment of Acute Hyperkalaemia in Adults · reviewed 2026-08-26
כרטיס 449
שאלה
Which bedside pattern best points to community-acquired pneumonia?
תשובה
New cough, fever, dyspnea, pleuritic pain, and focal crackles suggest pneumonia, but clinical findings alone are imperfect.
Diagnosis and Treatment of Adults with Community-acquired Pneumonia · reviewed 2026-08-26
כרטיס 450
שאלה
Which pharmacologic approach is preferred for heart failure with reduced ejection fraction?
תשובה
Foundational chronic therapy includes an ARNI or ACE inhibitor/ARB, an evidence-based beta-blocker, an MRA, and an SGLT2 inhibitor when tolerated.
2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure · reviewed 2026-08-26
כרטיס 451
שאלה
For surgical decision-making, severe dyspnea, unilateral absent breath sounds, hypotension, distended neck veins, and obstructive shock indicate which diagnosis?
תשובה
Tension pneumothorax. Severe dyspnea, unilateral absent breath sounds, hypotension, distended neck veins, and obstructive shock suggest tension physiology.
Thoracic Trauma WSES-AAST Guidelines · reviewed 2026-08-26
כרטיס 452
שאלה
Which bedside pattern best points to ectopic pregnancy?
תשובה
Unilateral pelvic pain or bleeding in early pregnancy, especially with syncope or shoulder pain, raises concern for ectopic implantation.
Ectopic Pregnancy · reviewed 2026-08-26
כרטיס 453
שאלה
In a child with sickle cell disease, sudden severe limb or back pain matches prior vaso-occlusive episodes and no alternative cause is found. Which diagnosis best fits?
תשובה
Acute sickle cell vaso-occlusive pain episode.
ASH 2020 Guidelines for Sickle Cell Disease: Management of Acute and Chronic Pain · reviewed 2026-08-26
כרטיס 454
שאלה
In a child or adolescent, which bedside pattern best points to major depressive disorder?
תשובה
At least two weeks of depressed mood or loss of interest with functional change and associated neurovegetative or cognitive symptoms suggests major depression.
Clinical Practice Guideline for the Assessment and Treatment of Children and Adolescents With Major and Persistent Depressive Disorders · reviewed 2026-08-26
כרטיס 455
שאלה
Which prevention or risk-reduction step is important for cirrhosis with ascites?
תשובה
Use sodium restriction, review medicines that can worsen kidney perfusion, and monitor weight, kidney function, and electrolytes.
Diagnosis, Evaluation, and Management of Ascites, Spontaneous Bacterial Peritonitis and Hepatorenal Syndrome · reviewed 2026-08-26
כרטיס 456
שאלה
What clinical clue should raise suspicion for type 2 diabetes mellitus?
תשובה
Polyuria, polydipsia, blurred vision, recurrent infections, or an asymptomatic high-risk patient may reveal hyperglycemia.
Standards of Care in Diabetes—2026 · reviewed 2026-08-26
כרטיס 457
שאלה
In a postmenopausal woman or man aged 50 or older, which steps support bone health and reduce fracture risk?
תשובה
Adequate calcium and vitamin D, weight-bearing and muscle-strengthening exercise, fall-risk reduction, tobacco cessation, and avoiding excess alcohol support bone health.
The clinician’s guide to prevention and treatment of osteoporosis · reviewed 2026-08-26
כרטיס 458
שאלה
What clinical clue should raise suspicion for acute angle-closure glaucoma?
תשובה
Sudden painful red eye, blurred vision with halos, headache, nausea, a fixed mid-dilated pupil, and a firm globe are classic.
Management of Angle-Closure Glaucoma · reviewed 2026-08-26
כרטיס 459
שאלה
How should a clinician respond to an incidental finding outside the visit’s main problem?
תשובה
Explain the finding and its uncertainty, recommend proportionate follow-up, assign ownership, and document the plan.
Catching Those Who Fall Through the Cracks: Follow-up for Incidental Radiologic Findings · reviewed 2026-08-26
כרטיס 460
שאלה
Which next action matters most in ventricular fibrillation cardiac arrest?
תשובה
Start high-quality CPR and defibrillate ventricular fibrillation or pulseless ventricular tachycardia as soon as possible.
2025 American Heart Association Guidelines for CPR and ECC: Adult Advanced Life Support · reviewed 2026-08-26
כרטיס 461
שאלה
Which test or testing sequence best evaluates suspected plaque psoriasis?
תשובה
Diagnosis is usually clinical; biopsy is reserved for uncertain morphology.
Psoriasis Clinical Guidelines · reviewed 2026-08-26
כרטיס 462
שאלה
What is the priority management step for pulmonary embolism?
תשובה
Start anticoagulation for confirmed pulmonary embolism; consider thrombolysis for selected patients with hemodynamic compromise and acceptable bleeding risk.
ASH VTE Guidelines: Treatment of Deep Vein Thrombosis and Pulmonary Embolism · reviewed 2026-08-26
כרטיס 463
שאלה
What diagnostic approach is most appropriate when uncomplicated cystitis is suspected?
תשובה
Urinalysis supports the diagnosis; culture is important for complicated, recurrent, resistant, pregnant, or atypical cases.
EAU Guidelines on Urological Infections · reviewed 2026-08-26
כרטיס 464
שאלה
How should a clinician initially manage migraine with aura?
תשובה
Treat early with an effective acute medicine and choose prevention when frequency or disability justifies it.
AHS Consensus Statement: Integrating New Migraine Treatments into Clinical Practice · reviewed 2026-08-26
כרטיס 465
שאלה
Why does thrombotic thrombocytopenic purpura produce its defining clinical pattern?
תשובה
Severe ADAMTS13 deficiency permits ultra-large von Willebrand factor multimers to form platelet-rich microthrombi.
ISTH Guidelines for the Diagnosis and Treatment of Thrombotic Thrombocytopenic Purpura · reviewed 2026-08-26
כרטיס 466
שאלה
How should a clinician initially manage early syphilis?
תשובה
Treat the patient and ensure partner evaluation; urgent specialist evaluation is needed for ocular, otic, or neurologic disease.
Primary and Secondary Syphilis: STI Treatment Guidelines · reviewed 2026-08-26
כרטיס 467
שאלה
What diagnostic approach is most appropriate when atrial fibrillation is suspected?
תשובה
Confirm the rhythm with a 12-lead ECG and assess for structural disease and reversible triggers.
2023 ACC/AHA/ACCP/HRS Guideline for Atrial Fibrillation: Key Perspectives · reviewed 2026-08-26
כרטיס 468
שאלה
How should a clinician initially manage abnormal uterine bleeding from anovulation?
תשובה
Stabilize acute heavy bleeding first, then protect the endometrium and control ongoing blood loss.
Management of Acute Abnormal Uterine Bleeding in Nonpregnant Reproductive-Aged Women · reviewed 2026-08-26
כרטיס 469
שאלה
Why does acute cholecystitis produce its defining clinical pattern?
תשובה
A gallstone can block bile flow, causing gallbladder pain and swelling (inflammation).
Cholecystectomy · reviewed 2026-08-26
כרטיס 470
שאלה
How should a clinician initially manage post-traumatic stress disorder?
תשובה
Offer individual trauma-focused psychotherapy as first-line treatment when available and acceptable.
Management of Posttraumatic Stress Disorder and Acute Stress Disorder · reviewed 2026-08-26
כרטיס 471
שאלה
In a child or adolescent, a clinician is considering septic arthritis. Which finding adds the most support?
תשובה
Acute severe monoarticular pain, restricted passive motion, fever, or bacteremia risk is septic arthritis until excluded.
Guideline for Management of Septic Arthritis in Native Joints · reviewed 2026-08-26
כרטיס 472
שאלה
Which next action matters most in acute kidney injury?
תשובה
Treat the cause, restore perfusion without overload, stop nephrotoxins, and relieve obstruction.
KDIGO Clinical Practice Guideline for Acute Kidney Injury · reviewed 2026-08-26
כרטיס 473
שאלה
For an eligible infant or selected high-risk child aged 8–19 months, which immunization strategy reduces severe RSV disease?
תשובה
Use either maternal RSV vaccination or a recommended long-acting RSV antibody to protect infants; give nirsevimab to eligible high-risk children aged 8–19 months entering a second RSV season.
RSV Immunization Guidance for Infants and Young Children · reviewed 2026-08-26
כרטיס 474
שאלה
Which diagnosis causes weight loss, fatigue, hypotension, salt craving, hyperpigmentation, hyponatremia, and hyperkalemia?
תשובה
Primary adrenal insufficiency. Weight loss, fatigue, hypotension, salt craving, hyperpigmentation, hyponatremia, and hyperkalemia suggest primary adrenal failure.
Primary Adrenal Insufficiency Guideline Resources · reviewed 2026-08-26
כרטיס 475
שאלה
What is the ethical approach to a learner performing a procedure?
תשובה
Tell the patient who will participate, describe supervision, obtain voluntary agreement, and ensure refusal does not compromise care.
Residents and Fellows: Patient Involvement in Self-Education · reviewed 2026-08-26
כרטיס 476
שאלה
In a child aged 6 months or older, what condition should be suspected from a bulging tympanic membrane with acute ear pain or new otorrhea?
תשובה
Acute otitis media. A bulging tympanic membrane with acute ear pain or new otorrhea is more specific than redness alone.
Management of Acute Otitis Media in Children Six Months of Age and Older · reviewed 2026-08-26
כרטיס 477
שאלה
Which bedside pattern best points to acute coronary syndrome?
תשובה
Pressure-like substernal pain with diaphoresis, nausea, or radiation to the arm or jaw is a classic ischemic pattern.
2025 ACC/AHA Guideline for the Management of Patients With Acute Coronary Syndromes · reviewed 2026-08-26
כרטיס 478
שאלה
How should medication be used in multiple sclerosis relapse?
תשובה
High-dose corticosteroids shorten a disabling relapse; they do not alter long-term progression by themselves.
Multiple Sclerosis in Adults: Management · reviewed 2026-08-26
כרטיס 479
שאלה
What immediate plan is appropriate for acute pancreatitis?
תשובה
Use early isotonic fluids guided by response, analgesia, and early oral feeding as tolerated; address the cause.
ACG Clinical Guideline: Management of Acute Pancreatitis · reviewed 2026-08-26
כרטיס 480
שאלה
How should medication be used in HIV infection?
תשובה
Use a recommended combination antiretroviral regimen selected for resistance, interactions, comorbidity, pregnancy potential, and patient preference.
What to Start: Initial Combination Antiretroviral Regimens · reviewed 2026-08-26
כרטיס 481
שאלה
For surgical decision-making, what immediate plan is appropriate for anterior cruciate ligament tear?
תשובה
Control swelling, restore motion, begin rehabilitation, and individualize reconstruction by instability and activity goals.
Management of Anterior Cruciate Ligament Injuries: Evidence-Based Clinical Practice Guideline · reviewed 2026-08-26
כרטיס 482
שאלה
How should medication be used in postpartum hemorrhage?
תשובה
Oxytocin is first-line for uterine atony; add other uterotonics according to contraindications and give tranexamic acid early when indicated.
Postpartum Hemorrhage · reviewed 2026-08-26
כרטיס 483
שאלה
In a child or adolescent, which history or examination finding most strongly supports asthma?
תשובה
Variable wheeze, cough, chest tightness, or dyspnea that changes over time and with triggers suggests asthma.
2026 GINA Strategy Report · reviewed 2026-08-26
כרטיס 484
שאלה
How should medication be used in delirium?
תשובה
Reserve short-term antipsychotic use for severe dangerous agitation after reversible causes and contraindications are addressed.
Delirium: Prevention, Diagnosis and Management · reviewed 2026-08-26
כרטיס 485
שאלה
Which preventive measure belongs in care for herpes zoster?
תשובה
Age-appropriate recombinant zoster vaccination lowers zoster and postherpetic-neuralgia risk.
Clinical Overview of Shingles (Herpes Zoster) · reviewed 2026-08-26
כרטיס 486
שאלה
For surgical decision-making, what condition should be suspected from this finding: Abrupt severe chest or back pain, pulse or blood-pressure asymmetry, and a new aortic regurgitation murmur are high-risk clues.
תשובה
Aortic dissection. Abrupt severe chest or back pain, pulse or blood-pressure asymmetry, and a new aortic regurgitation murmur are high-risk clues.
2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease · reviewed 2026-08-26
כרטיס 487
שאלה
Which preventive step is required during surgery for viable testicular torsion?
תשובה
Perform bilateral orchiopexy, fixing the affected and contralateral testes to reduce future torsion risk.
Testicular Torsion · reviewed 2026-08-26
כרטיס 488
שאלה
Which test or testing sequence best evaluates suspected hyponatremia due to SIADH?
תשובה
Confirm low serum osmolality with inappropriately concentrated urine and urine sodium after excluding thyroid, adrenal, renal, and diuretic causes.
Clinical Practice Guideline on Diagnosis and Treatment of Hyponatraemia · reviewed 2026-08-26
כרטיס 489
שאלה
Why does primary hypothyroidism produce its defining clinical pattern?
תשובה
Low thyroid hormone removes feedback inhibition, so TSH rises in primary gland failure.
Guidelines for the Treatment of Hypothyroidism · reviewed 2026-08-26
כרטיס 490
שאלה
Which test or testing sequence best evaluates suspected neutropenic fever?
תשובה
Obtain blood cultures and targeted cultures or imaging, but do not delay empiric antibiotics.
Outpatient Management of Fever and Neutropenia in Adults Treated for Malignancy · reviewed 2026-08-26
כרטיס 491
שאלה
Why does bacterial conjunctivitis produce its defining clinical pattern?
תשובה
Bacterial infection of the conjunctiva commonly produces red eye with purulent discharge that mats the eyelids.
Clinical Overview of Pink Eye (Conjunctivitis) · reviewed 2026-08-26
כרטיס 492
שאלה
When is a chaperone appropriate for an intimate examination?
תשובה
Offer a trained chaperone, respect patient preferences when safety permits, explain the examination, obtain consent, and document who was present.
Use of Chaperones · reviewed 2026-08-26
כרטיס 493
שאלה
Which diagnosis causes recurrent unilateral pulsating headache with nausea or sensory sensitivity, preceded by gradually spreading reversible visual or sensory symptoms?
תשובה
Migraine with aura. Recurrent unilateral pulsating headache with nausea or sensory sensitivity, preceded by gradually spreading reversible visual or sensory symptoms, suggests migraine with aura.
ICHD-3: Migraine with Aura · reviewed 2026-08-26
כרטיס 494
שאלה
What medication strategy is appropriate for Crohn disease?
תשובה
Corticosteroids can induce remission but are not maintenance therapy; immunomodulator or biologic selection depends on risk and phenotype.
Updated 2025 ACG Guidelines for Crohn’s Disease · reviewed 2026-08-26
כרטיס 495
שאלה
Which diagnosis best fits a painless chancre or a diffuse rash involving the palms and soles with generalized lymphadenopathy?
תשובה
Early syphilis. A painless chancre or a diffuse rash involving palms and soles with generalized lymphadenopathy suggests syphilis by stage.
Primary and Secondary Syphilis: STI Treatment Guidelines · reviewed 2026-08-26
כרטיס 496
שאלה
What medication strategy is appropriate for rheumatoid arthritis?
תשובה
Methotrexate is a preferred anchor drug for many patients with moderate-to-high activity, with folate and safety monitoring.
2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis · reviewed 2026-08-26
כרטיס 497
שאלה
Which diagnosis best fits irregular, unpredictable uterine bleeding at reproductive extremes or with endocrine disruption?
תשובה
Abnormal uterine bleeding from anovulation. Irregular unpredictable bleeding without cyclic ovulation is common at reproductive extremes or with endocrine disruption.
Abnormal Uterine Bleeding · reviewed 2026-08-26
כרטיס 498
שאלה
Which medication class does the 2024 SCCM focused update suggest for an adult with acute respiratory distress syndrome?
תשובה
Use systemic corticosteroids in selected adults with ARDS; the guideline does not specify one best molecule, dose, or duration.
2024 Focused Update: Corticosteroids in Sepsis, ARDS, and Community-Acquired Pneumonia · reviewed 2026-08-26
כרטיס 499
שאלה
Which diagnosis requires intrusion, avoidance, negative mood or cognition, and hyperarousal lasting more than one month after trauma?
תשובה
Post-traumatic stress disorder. Intrusion, avoidance, negative mood or cognition, and hyperarousal lasting over a month after trauma suggest PTSD.
Management of Posttraumatic Stress Disorder and Acute Stress Disorder · reviewed 2026-08-26
כרטיס 500
שאלה
Which preventive measure belongs in care for acute pericarditis?
תשובה
Restrict strenuous activity until symptoms and inflammatory findings resolve.
2025 Concise Clinical Guidance: Diagnosis and Management of Pericarditis · reviewed 2026-08-26
כרטיס 501
שאלה
Which diagnosis best fits loud snoring, witnessed apneas, gasping, daytime sleepiness, morning headache, or resistant hypertension?
תשובה
Obstructive sleep apnea. Loud snoring, witnessed apneas, gasping, daytime sleepiness, morning headache, or resistant hypertension suggests OSA.
Clinical Practice Guideline for Diagnostic Testing for Adult Obstructive Sleep Apnea · reviewed 2026-08-26
כרטיס 502
שאלה
What drug class or regimen fits atrial fibrillation?
תשובה
Choose anticoagulation from validated thromboembolic-risk assessment; direct oral anticoagulants are preferred for most eligible patients without mechanical valves or moderate-to-severe rheumatic mitral stenosis.
2023 ACC/AHA/ACCP/HRS Guideline for Atrial Fibrillation: Key Perspectives · reviewed 2026-08-26
כרטיס 503
שאלה
In a child or adolescent, which history or examination finding most strongly supports acute appendicitis?
תשובה
Periumbilical pain migrating to the right lower quadrant with anorexia, nausea, fever, and focal tenderness is typical.
Guideline for the Diagnosis and Treatment of Appendicitis · reviewed 2026-08-26
כרטיס 504
שאלה
Which diagnosis best fits this presentation: Nocturnal numbness or tingling in the thumb, index, and middle fingers with thenar weakness suggests median-nerve compression.
תשובה
Carpal tunnel syndrome. Nocturnal numbness or tingling in the thumb, index, and middle fingers with thenar weakness suggests median-nerve compression.
Management of Carpal Tunnel Syndrome: Evidence-Based Clinical Practice Guideline · reviewed 2026-08-26
כרטיס 505
שאלה
In an adult with headaches consistent with migraine with aura and a normal neurologic examination, when is neuroimaging needed?
תשובה
Routine neuroimaging is unnecessary; consider it when the aura is unusual, prolonged, or persistent or when other atypical or red-flag features are present.
Neuroimaging for Migraine: The American Headache Society Systematic Review and Evidence-Based Guideline · reviewed 2026-08-26
כרטיס 506
שאלה
In a child or adolescent, how can a clinician reduce avoidable harm related to diabetic ketoacidosis?
תשובה
Sick-day planning, continued basal insulin, ketone checks, and early contact for illness reduce recurrence.
Standards of Care in Diabetes—2026 · reviewed 2026-08-26
כרטיס 507
שאלה
How should a clinician confirm or characterize early syphilis?
תשובה
Use a nontreponemal test with a treponemal confirmatory test, or the reverse sequence; evaluate neurologic or ocular symptoms separately.
Primary and Secondary Syphilis: STI Treatment Guidelines · reviewed 2026-08-26
כרטיס 508
שאלה
How can a clinician reduce avoidable harm related to retinal detachment?
תשובה
Assess sudden new floaters, flashes, or a curtain immediately; early treatment can prevent permanent vision loss. Dilated examination can find a small tear or detachment before vision is affected.
Retinal Detachment · reviewed 2026-08-26
כרטיס 509
שאלה
How should a clinician confirm or characterize abnormal uterine bleeding from anovulation?
תשובה
Exclude pregnancy, assess anemia, review medicines and systemic causes, and sample endometrium when age or risk warrants.
Management of Acute Abnormal Uterine Bleeding in Nonpregnant Reproductive-Aged Women · reviewed 2026-08-26
כרטיס 510
שאלה
How should social media be handled when a clinical story seems de-identified?
תשובה
Do not post patient material without proper authorization; combinations of details can identify a person even when names are removed.
Professionalism in the Use of Social Media · reviewed 2026-08-26
כרטיס 511
שאלה
How should a clinician confirm or characterize post-traumatic stress disorder?
תשובה
Use a trauma-informed clinical assessment and a validated symptom measure while checking safety and comorbidity.
Management of Posttraumatic Stress Disorder and Acute Stress Disorder · reviewed 2026-08-26
כרטיס 512
שאלה
Which preventive measure belongs in care for nephrotic syndrome?
תשובה
Vaccination, thrombosis-risk assessment, infection prevention, and cardiovascular-risk control reduce complications.
KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases with 2024 Chapter Updates · reviewed 2026-08-26
כרטיס 513
שאלה
In a child or adolescent, what medication strategy is appropriate for atopic dermatitis?
תשובה
Topical corticosteroids are first-line for most flares; steroid-sparing topical agents help at sensitive sites or with maintenance.
Atopic Dermatitis Clinical Guidelines · reviewed 2026-08-26
כרטיס 514
שאלה
Which preventive measure belongs in care for thrombotic thrombocytopenic purpura?
תשובה
Recognize relapse symptoms early and maintain specialist follow-up after recovery.
ISTH Guidelines for the Diagnosis and Treatment of Thrombotic Thrombocytopenic Purpura · reviewed 2026-08-26
כרטיס 515
שאלה
How should a clinician initially manage acute coronary syndrome?
תשובה
Give aspirin promptly when acute coronary syndrome is suspected and no contraindication exists; activate reperfusion pathways for STEMI.
2025 ACC/AHA Guideline for the Management of Patients With Acute Coronary Syndromes · reviewed 2026-08-26
כרטיס 516
שאלה
Which history or examination finding most strongly supports acute pyelonephritis?
תשובה
Fever, flank pain, costovertebral-angle tenderness, nausea, and urinary symptoms suggest renal infection.
EAU Guidelines on Urological Infections · reviewed 2026-08-26
כרטיס 517
שאלה
For surgical decision-making, which next action matters most in tension pneumothorax?
תשובה
Perform immediate decompression followed by tube thoracostomy.
Thoracic Trauma WSES-AAST Guidelines · reviewed 2026-08-26
כרטיס 518
שאלה
Which diagnosis best fits this presentation: Chronic diarrhea, bloating, weight loss, iron deficiency, dermatitis herpetiformis, or unexplained osteoporosis can be the clue.
תשובה
Celiac disease. Chronic diarrhea, bloating, weight loss, iron deficiency, dermatitis herpetiformis, or unexplained osteoporosis can be the clue.
ACG Clinical Guidelines: Diagnosis and Management of Celiac Disease · reviewed 2026-08-26
כרטיס 519
שאלה
What physiologic disturbance underlies anterior cruciate ligament tear?
תשובה
An ACL tear removes a primary restraint to anterior tibial translation and rotation, producing anterior and rotational instability.
The Management of Anterior Cruciate Ligament Injuries · reviewed 2026-08-26
כרטיס 520
שאלה
A clinician is considering heart failure with reduced ejection fraction. Which finding adds the most support?
תשובה
Exertional dyspnea, orthopnea, edema, elevated jugular venous pressure, and an S3 support volume-overloaded heart failure.
2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure · reviewed 2026-08-26
כרטיס 521
שאלה
What physiologic disturbance underlies bacterial brain abscess?
תשובה
Localized infection produces cerebritis and a capsule with surrounding edema and mass effect.
ESCMID Guideline on Diagnosis and Treatment of Brain Abscess in Children and Adults · reviewed 2026-08-26
כרטיס 522
שאלה
What is the key first diagnostic step for Cushing syndrome?
תשובה
Use an accepted first-line screen such as late-night salivary cortisol, 24-hour urinary free cortisol, or overnight dexamethasone suppression.
Diagnosis of Cushing Syndrome: An Endocrine Society Clinical Practice Guideline · reviewed 2026-08-26
כרטיס 523
שאלה
What physiologic disturbance underlies pulmonary tuberculosis?
תשובה
Mycobacteria survive in macrophages and drive granulomatous inflammation with latent or active disease.
Clinical Overview of Tuberculosis Disease · reviewed 2026-08-26
כרטיס 524
שאלה
Which antibiotic is required for gonococcal conjunctivitis in an adult?
תשובה
Give systemic ceftriaxone; consider one-time saline lavage and evaluate for chlamydial coinfection when it has not been excluded.
Gonococcal Infections Among Adolescents and Adults · reviewed 2026-08-26
כרטיס 525
שאלה
What physiologic disturbance underlies endometriosis?
תשובה
Estrogen-responsive ectopic endometrial-like tissue drives inflammation, fibrosis, and pain.
Endometriosis · reviewed 2026-08-26
כרטיס 526
שאלה
What should a clinician do after sending protected information to the wrong recipient?
תשובה
Act immediately to limit further disclosure, notify the organization’s privacy or security process, document facts, and follow breach assessment requirements.
Breach Notification Rule · reviewed 2026-08-26
כרטיס 527
שאלה
Which clinical pattern defines a panic attack?
תשובה
An abrupt surge of intense fear or discomfort with physical and cognitive symptoms that peaks within minutes defines a panic attack.
Panic Disorder: What You Need to Know · reviewed 2026-08-26
כרטיס 528
שאלה
What clinical clue should raise suspicion for acute kidney injury?
תשובה
A rising creatinine or falling urine output after illness, volume loss, nephrotoxin exposure, obstruction, or sepsis indicates AKI.
KDIGO Clinical Practice Guideline for Acute Kidney Injury · reviewed 2026-08-26
כרטיס 529
שאלה
What physiologic disturbance underlies tension pneumothorax?
תשובה
A one-way pleural air leak raises intrathoracic pressure, collapses the lung, and impairs venous return.
Thoracic Trauma WSES-AAST Guidelines · reviewed 2026-08-26
כרטיס 530
שאלה
In a child or adolescent, what clinical clue should raise suspicion for immune thrombocytopenia?
תשובה
Isolated petechiae, bruising, or mucosal bleeding with thrombocytopenia and otherwise preserved cell lines suggests ITP.
American Society of Hematology 2019 Guidelines for Immune Thrombocytopenia · reviewed 2026-08-26
כרטיס 531
שאלה
What is the key first diagnostic step for celiac disease?
תשובה
Order tissue-transglutaminase IgA with total IgA while the patient is eating gluten; confirm as guideline-directed.
ACG Clinical Guidelines: Diagnosis and Management of Celiac Disease · reviewed 2026-08-26
כרטיס 532
שאלה
A patient has this pattern: Fever plus a new or changing murmur, embolic findings, injection-drug use, or prosthetic material raises suspicion. What is the most likely diagnosis?
תשובה
Infective endocarditis. Fever plus a new or changing murmur, embolic findings, injection-drug use, or prosthetic material raises suspicion.
2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease · reviewed 2026-08-26
כרטיס 533
שאלה
What is the key first diagnostic step for carpal tunnel syndrome?
תשובה
Diagnosis is often clinical; electrodiagnostic testing helps when severe, atypical, or before selected surgery.
Management of Carpal Tunnel Syndrome: Evidence-Based Clinical Practice Guideline · reviewed 2026-08-26
כרטיס 534
שאלה
Which prevention step is essential before oral intake in acute ischemic stroke?
תשובה
Screen swallowing before food, fluids, or oral medication to reduce aspiration risk.
2026 Guideline for the Early Management of Patients With Acute Ischemic Stroke · reviewed 2026-08-26
כרטיס 535
שאלה
What is the priority management step for cellulitis?
תשובה
Mark the margin, assess for abscess or necrotizing infection, and escalate care for systemic toxicity.
Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections · reviewed 2026-08-26
כרטיס 536
שאלה
Which prevention or risk-reduction step is important for community-acquired pneumonia?
תשובה
Keep age- and risk-appropriate pneumococcal vaccination current to reduce preventable pneumococcal pneumonia.
Pneumococcal Vaccine Recommendations · reviewed 2026-08-26
כרטיס 537
שאלה
For surgical decision-making, what is the priority management step for benign prostatic hyperplasia?
תשובה
Urgently catheterize acute urinary retention and evaluate infection, kidney injury, or severe hematuria.
EAU Guidelines on the Management of Non-neurogenic Male Lower Urinary Tract Symptoms · reviewed 2026-08-26
כרטיס 538
שאלה
Which prevention or risk-reduction step is important for ectopic pregnancy?
תשובה
Early testing after a missed period and prompt evaluation of pain or bleeding reduce rupture morbidity.
Ectopic Pregnancy · reviewed 2026-08-26
כרטיס 539
שאלה
What diagnostic approach is most appropriate when obstructive sleep apnea is suspected?
תשובה
Confirm with polysomnography or an appropriate home sleep-apnea test in selected uncomplicated adults.
Clinical Practice Guideline for Diagnostic Testing for Adult Obstructive Sleep Apnea · reviewed 2026-08-26
כרטיס 540
שאלה
In a child or adolescent, which prevention or risk-reduction step is important for major depressive disorder?
תשובה
Monitor symptoms, suicidality, functioning, treatment adherence, and recurrence with a clear follow-up and safety plan.
Clinical Practice Guideline for the Assessment and Treatment of Children and Adolescents With Major and Persistent Depressive Disorders · reviewed 2026-08-26
כרטיס 541
שאלה
Which pathophysiologic process drives symptomatic aortic stenosis?
תשובה
Calcific leaflet narrowing creates a fixed left-ventricular outflow obstruction and pressure overload.
2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease · reviewed 2026-08-26
כרטיס 542
שאלה
In a child or adolescent, what drug class or regimen fits diabetic ketoacidosis?
תשובה
Use continuous IV regular insulin; add dextrose as glucose falls so ketone clearance can continue.
Standards of Care in Diabetes—2026 · reviewed 2026-08-26
כרטיס 543
שאלה
What is the key first diagnostic step for peritonsillar abscess?
תשובה
Diagnosis is usually clinical; ultrasound or CT helps when the diagnosis or deep-space extension is uncertain.
Tonsillitis and Peritonsillar Abscess · reviewed 2026-08-26
כרטיס 544
שאלה
What does continuity require before ending a clinician-patient relationship?
תשובה
Give reasonable notice, provide urgent coverage during the transition, offer transfer resources, and make records available as permitted.
Terminating a Patient-Physician Relationship · reviewed 2026-08-26
כרטיס 545
שאלה
What counseling point helps reduce harm from chronic hepatitis C?
תשובה
Avoid blood exposure, do not share injection equipment, and screen all adults and each pregnancy as recommended.
Viral Hepatitis Clinical Care · reviewed 2026-08-26
כרטיס 546
שאלה
What drug class or regimen fits hyperkalemia?
תשובה
IV calcium protects the heart; insulin with glucose shifts potassium, while diuresis, binders, or dialysis remove it.
Clinical Practice Guideline: Treatment of Acute Hyperkalaemia in Adults · reviewed 2026-08-26
כרטיס 547
שאלה
In a child or adolescent, what counseling point helps reduce harm from juvenile idiopathic arthritis?
תשובה
Vaccination, eye screening, activity, and growth monitoring reduce preventable morbidity.
2026 Juvenile Idiopathic Arthritis Guidelines · reviewed 2026-08-26
כרטיס 548
שאלה
In a child or adolescent, which next action matters most in immune thrombocytopenia?
תשובה
Treat clinically important bleeding urgently; observation is appropriate for selected patients with minor symptoms.
American Society of Hematology 2019 Guidelines for Immune Thrombocytopenia · reviewed 2026-08-26
כרטיס 549
שאלה
A clinician is considering subarachnoid hemorrhage. Which finding adds the most support?
תשובה
A sudden maximal-at-onset thunderclap headache, neck stiffness, vomiting, or brief loss of consciousness is concerning.
2023 Guideline for Aneurysmal Subarachnoid Hemorrhage · reviewed 2026-08-26
כרטיס 550
שאלה
Which test or testing sequence best evaluates suspected aortic dissection?
תשובה
CT angiography is the usual rapid definitive study in a stable patient; transesophageal echocardiography is useful when unstable.
2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease · reviewed 2026-08-26
כרטיס 551
שאלה
In a child, typically 6 months to 3 years, what counseling point helps reduce harm from croup?
תשובה
Caregivers should seek urgent assessment for stridor at rest, marked chest retractions, cyanosis, lethargy, or poor air entry.
Acute Management of Croup in the Emergency Department · reviewed 2026-08-26
כרטיס 552
שאלה
In a child or adolescent, a clinician is considering bacterial meningitis. Which finding adds the most support?
תשובה
Fever, headache, neck stiffness, altered mental status, or a nonblanching rash should trigger urgent evaluation.
WHO Guidelines on Meningitis Diagnosis, Treatment and Care · reviewed 2026-08-26
כרטיס 553
שאלה
A clinician is considering preeclampsia with severe features. Which finding adds the most support?
תשובה
New hypertension after 20 weeks with end-organ findings such as severe pressure, thrombocytopenia, liver injury, kidney injury, pulmonary edema, or neurologic symptoms suggests severe disease.
Gestational Hypertension and Preeclampsia · reviewed 2026-08-26
כרטיס 554
שאלה
A clinician is considering bipolar I mania. Which finding adds the most support?
תשובה
At least one week of elevated or irritable mood with increased energy, decreased sleep, pressured speech, grandiosity, and risky behavior suggests mania.
Management of Bipolar Disorder in Adults · reviewed 2026-08-26
כרטיס 555
שאלה
What is the priority management step for celiac disease?
תשובה
Do not start a gluten-free diet before completing diagnostic testing unless immediate clinical needs demand it.
ACG Clinical Guidelines: Diagnosis and Management of Celiac Disease · reviewed 2026-08-26
כרטיס 556
שאלה
Which history or examination finding most strongly supports acute compartment syndrome?
תשובה
Pain out of proportion, pain with passive stretch, tense swelling, and progressive neurologic deficits after injury are warning signs.
Management of Acute Compartment Syndrome: Evidence-Based Clinical Practice Guideline · reviewed 2026-08-26
כרטיס 557
שאלה
For surgical decision-making, how should a clinician initially manage Cushing syndrome?
תשובה
Confirm hypercortisolism, identify whether it is ACTH dependent, and localize the source before definitive treatment.
Treatment of Cushing Syndrome: An Endocrine Society Clinical Practice Guideline · reviewed 2026-08-26
כרטיס 558
שאלה
Which bedside pattern best points to retinal detachment?
תשובה
New flashes, floaters, and a curtain or shadow across the visual field suggest detachment.
Retinal Detachment · reviewed 2026-08-26
כרטיס 559
שאלה
How should a clinician respond when requested to falsify a work note or record?
תשובה
Decline, document objective facts accurately, explain what can truthfully be certified, and preserve the integrity of the record.
Management of Medical Records · reviewed 2026-08-26
כרטיס 560
שאלה
How can a clinician reduce avoidable harm related to hypertensive emergency?
תשובה
Accurate home monitoring and sustained treatment adherence reduce progression to crisis.
2025 High Blood Pressure Guideline · reviewed 2026-08-26
כרטיס 561
שאלה
What clinical clue should raise suspicion for COPD?
תשובה
Progressive exertional dyspnea, chronic cough or sputum, and exposure to tobacco, biomass, or occupational irritants suggest COPD.
2026 GOLD Report and Pocket Guide · reviewed 2026-08-26
כרטיס 562
שאלה
Which pharmacologic approach is preferred for acute pyelonephritis?
תשובה
Select empiric therapy from local resistance and severity, then narrow to the culture.
EAU Guidelines on Urological Infections · reviewed 2026-08-26
כרטיס 563
שאלה
Which history or examination finding most strongly supports plaque psoriasis?
תשובה
Well-demarcated erythematous plaques with silvery scale on extensor surfaces and nail pitting support psoriasis.
Psoriasis Clinical Guidelines · reviewed 2026-08-26
כרטיס 564
שאלה
What immediate plan is appropriate for Parkinson disease?
תשובה
Start multidisciplinary care and choose symptomatic treatment by functional impact, age, cognition, and adverse-effect risk.
Parkinson’s Disease in Adults · reviewed 2026-08-26
כרטיס 565
שאלה
Which diagnosis best fits hypotonic euvolemic hyponatremia with inappropriately concentrated urine after thyroid, adrenal, renal, and diuretic causes are excluded?
תשובה
Hyponatremia due to SIADH. Nausea, confusion, gait change, seizure, or subtle cognitive symptoms with hypotonic euvolemic hyponatremia may reflect SIADH.
Clinical Practice Guideline on Diagnosis and Treatment of Hyponatraemia · reviewed 2026-08-26
כרטיס 566
שאלה
What immediate plan is appropriate for gonococcal urethritis or cervicitis?
תשובה
Treat promptly, test for other STIs, abstain until treatment criteria are met, and arrange partner services.
Gonococcal Infections Among Adolescents and Adults · reviewed 2026-08-26
כרטיס 567
שאלה
How should medication be used in aortic dissection?
תשובה
Use an IV beta-blocker first to reduce shear stress, then add a vasodilator if pressure remains high.
2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease · reviewed 2026-08-26
כרטיס 568
שאלה
What immediate plan is appropriate for menopause vasomotor symptoms?
תשובה
Match treatment to symptom burden, uterus status, contraindications, and patient preference.
Hormone Therapy for Menopause · reviewed 2026-08-26
כרטיס 569
שאלה
Which pharmacologic approach is preferred for cirrhosis with ascites?
תשובה
Spironolactone with furosemide is a common diuretic combination when renal function and electrolytes allow.
Diagnosis, Evaluation, and Management of Ascites, Spontaneous Bacterial Peritonitis and Hepatorenal Syndrome · reviewed 2026-08-26
כרטיס 570
שאלה
What immediate plan is appropriate for alcohol withdrawal?
תשובה
Stabilize, give thiamine, use symptom- or risk-guided withdrawal treatment, and admit high-risk patients.
The ASAM Clinical Practice Guideline on Alcohol Withdrawal Management · reviewed 2026-08-26
כרטיס 571
שאלה
In a child or adolescent, what drug class or regimen fits sickle cell vaso-occlusive crisis?
תשובה
Use rapid individualized analgesia, with nonsteroidal anti-inflammatory drugs for selected mild pain and opioids for severe pain, followed by frequent reassessment.
ASH 2020 Guidelines for Sickle Cell Disease: Management of Acute and Chronic Pain · reviewed 2026-08-26
כרטיס 572
שאלה
For surgical decision-making, what is the priority management step for carpal tunnel syndrome?
תשובה
Use neutral-position night splinting initially; refer for decompression with severe weakness, denervation, or persistent symptoms.
Management of Carpal Tunnel Syndrome: Evidence-Based Clinical Practice Guideline · reviewed 2026-08-26
כרטיס 573
שאלה
In an infant aged 1–23 months, what drug class or regimen fits bronchiolitis?
תשובה
Routine salbutamol, corticosteroids, and antibiotics are not recommended; use antibiotics only when bacterial infection is evident or strongly suspected.
Bronchiolitis: Recommendations for Diagnosis, Monitoring and Management of Children One to 24 Months · reviewed 2026-08-26
כרטיס 574
שאלה
In a child or adolescent, which bedside pattern best points to diabetic ketoacidosis?
תשובה
Hyperglycemia with dehydration, abdominal pain, vomiting, Kussmaul respirations, or altered mental status suggests ketoacidosis.
Standards of Care in Diabetes—2026 · reviewed 2026-08-26
כרטיס 575
שאלה
For surgical decision-making, how should a clinician initially manage peritonsillar abscess?
תשובה
Assess the airway, drain the abscess, hydrate, and treat infection.
Tonsillitis and Peritonsillar Abscess · reviewed 2026-08-26
כרטיס 576
שאלה
Which factors determine a PA’s scope of practice?
תשובה
A PA’s education and experience, state law, practice-setting policy and credentialing, and the care team’s arrangements together define the services the PA may provide.
PA Scope of Practice · reviewed 2026-08-26
כרטיס 577
שאלה
What immediate plan is appropriate for heart failure with reduced ejection fraction?
תשובה
For acute pulmonary edema, support oxygenation and relieve congestion while identifying the trigger.
2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure · reviewed 2026-08-26
כרטיס 578
שאלה
What medication strategy is appropriate for acute ischemic stroke?
תשובה
Antiplatelet therapy is used after hemorrhage is excluded when thrombolysis timing and stroke mechanism allow.
2026 Guideline for the Early Management of Patients With Acute Ischemic Stroke · reviewed 2026-08-26
כרטיס 579
שאלה
What combination of findings should raise suspicion for acute calculous cholecystitis?
תשובה
Right-upper-quadrant pain or tenderness, fever, leukocytosis, and a positive Murphy sign support the diagnosis when considered together.
2020 World Society of Emergency Surgery Updated Guidelines for the Diagnosis and Treatment of Acute Calculous Cholecystitis · reviewed 2026-08-26
כרטיס 580
שאלה
What medication strategy is appropriate for community-acquired pneumonia?
תשובה
Use guideline-concordant empiric antibiotics based on setting, comorbidity, and local resistance; narrow when microbiology permits.
Diagnosis and Treatment of Adults with Community-acquired Pneumonia · reviewed 2026-08-26
כרטיס 581
שאלה
Which diagnosis is defined by acute hypoxemic respiratory failure with bilateral opacities not fully explained by cardiac failure after a known insult?
תשובה
Acute respiratory distress syndrome. Acute hypoxemic respiratory failure with bilateral opacities not fully explained by cardiac failure after a known insult suggests ARDS.
An Update on Management of Adult Patients with Acute Respiratory Distress Syndrome · reviewed 2026-08-26
כרטיס 582
שאלה
What medication strategy is appropriate for ectopic pregnancy?
תשובה
Methotrexate is an option for selected stable unruptured ectopic pregnancy without contraindications.
Ectopic Pregnancy · reviewed 2026-08-26
כרטיס 583
שאלה
In a child or adolescent, what medication strategy is appropriate for major depressive disorder?
תשובה
When medication is indicated for an adolescent, use an evidence-supported SSRI with close monitoring; combine it with psychotherapy according to severity and preference.
Clinical Practice Guideline for the Assessment and Treatment of Children and Adolescents With Major and Persistent Depressive Disorders · reviewed 2026-08-26
כרטיס 584
שאלה
In a child or adolescent, identify the condition from this pattern: Chronic pruritic eczematous patches with age-dependent flexural or facial distribution and a relapsing course are typical.
תשובה
Atopic dermatitis. Chronic pruritic eczematous patches with age-dependent flexural or facial distribution and a relapsing course are typical.
Atopic Dermatitis Clinical Guidelines · reviewed 2026-08-26
כרטיס 585
שאלה
Which pharmacologic approach is preferred for a postmenopausal woman with osteoporosis at high fracture risk?
תשובה
Bisphosphonates are first-line for many postmenopausal women at high fracture risk; consider anabolic therapy for very high risk.
Pharmacological Management of Osteoporosis in Postmenopausal Women · reviewed 2026-08-26
כרטיס 586
שאלה
Which history or examination finding most strongly supports atrial fibrillation?
תשובה
An irregularly irregular pulse with palpitations, fatigue, or dyspnea suggests atrial fibrillation.
2023 ACC/AHA/ACCP/HRS Guideline for Atrial Fibrillation: Key Perspectives · reviewed 2026-08-26
כרטיס 587
שאלה
Which diagnosis best fits dysuria and frequency without vaginal symptoms in an otherwise appropriate patient?
תשובה
Uncomplicated cystitis. Dysuria and frequency without vaginal symptoms strongly support lower urinary infection in an appropriate patient.
EAU Guidelines on Urological Infections · reviewed 2026-08-26
כרטיס 588
שאלה
How should a clinician initially manage nephrotic syndrome?
תשובה
Manage edema and cause, and urgently evaluate thrombosis, infection, or severe volume compromise.
KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases with 2024 Chapter Updates · reviewed 2026-08-26
כרטיס 589
שאלה
What condition should be suspected from this finding: A single fever in a patient with severe chemotherapy-related neutropenia is an emergency even when examination is unrevealing.
תשובה
Neutropenic fever. A single fever in a patient with severe chemotherapy-related neutropenia is an emergency even when examination is unrevealing.
Outpatient Management of Fever and Neutropenia in Adults Treated for Malignancy · reviewed 2026-08-26
כרטיס 590
שאלה
What is the purpose of root cause analysis after a serious patient-safety event?
תשובה
Identify active and latent system contributors, then design and track corrective actions that reduce recurrence rather than stopping at individual blame.
Root Cause Analysis · reviewed 2026-08-26
כרטיס 591
שאלה
For surgical decision-making, a patient has this pattern: Often asymptomatic hypercalcemia, nephrolithiasis, bone loss, constipation, or neurocognitive symptoms can be the clue. What is the most likely diagnosis?
תשובה
Primary hyperparathyroidism. Often asymptomatic hypercalcemia, nephrolithiasis, bone loss, constipation, or neurocognitive symptoms can be the clue.
Evaluation and Management of Primary Hyperparathyroidism: Fifth International Workshop Guidelines · reviewed 2026-08-26
כרטיס 592
שאלה
How should a clinician initially manage obstructive sleep apnea?
תשובה
Offer positive airway pressure for obstructive sleep apnea with excessive sleepiness and consider it for impaired sleep-related quality of life or comorbid hypertension.
Clinical Practice Guideline for Treatment of Adult Obstructive Sleep Apnea with Positive Airway Pressure · reviewed 2026-08-26
כרטיס 593
שאלה
A patient has this pattern: A rapid unilateral hearing decrease, often noticed on waking and sometimes with tinnitus, is an otologic emergency. What is the most likely diagnosis?
תשובה
Sudden sensorineural hearing loss. A rapid unilateral hearing decrease, often noticed on waking and sometimes with tinnitus, is an otologic emergency.
Clinical Practice Guideline: Sudden Hearing Loss (Update) · reviewed 2026-08-26
כרטיס 594
שאלה
Which diagnosis requires bradykinesia plus rest tremor or rigidity and often includes reduced arm swing or a shuffling gait?
תשובה
Parkinson disease. Bradykinesia plus rest tremor or rigidity, with reduced arm swing and shuffling gait, supports parkinsonism.
Parkinson’s Disease in Adults · reviewed 2026-08-26
כרטיס 595
שאלה
Which diagnosis best fits purulent urethral discharge, dysuria, cervicitis, pelvic pain, or a relevant sexual exposure, although infection may be asymptomatic?
תשובה
Gonococcal urethritis or cervicitis. Purulent urethral discharge, dysuria, cervicitis, pelvic pain, or exposure may indicate gonorrhea, but infection can be asymptomatic.
Gonococcal Infections Among Adolescents and Adults · reviewed 2026-08-26
כרטיס 596
שאלה
Which diagnosis best fits hot flashes, night sweats, sleep disruption, and menstrual transition at the expected age?
תשובה
Menopause vasomotor symptoms. Hot flashes, night sweats, sleep disruption, and menstrual transition at the expected age usually identify menopausal vasomotor symptoms.
The Menopause Years · reviewed 2026-08-26
כרטיס 597
שאלה
Which diagnosis causes tremor, autonomic hyperactivity, insomnia, nausea, anxiety, hallucinations, or seizures after reducing heavy alcohol use?
תשובה
Alcohol withdrawal. Tremor, autonomic hyperactivity, insomnia, nausea, anxiety, hallucinations, or seizures after reducing heavy alcohol use suggests withdrawal.
The ASAM Clinical Practice Guideline on Alcohol Withdrawal Management · reviewed 2026-08-26
כרטיס 598
שאלה
Which diagnosis causes bloody diarrhea, urgency, tenesmus, and crampy abdominal pain with continuous colonic inflammation?
תשובה
Ulcerative colitis. Bloody diarrhea, urgency, tenesmus, and crampy abdominal pain with continuous colonic inflammation suggest ulcerative colitis.
Updated 2025 ACG Guidelines to Manage Adult Ulcerative Colitis Patients · reviewed 2026-08-26
כרטיס 599
שאלה
Which diagnosis best fits abrupt severe monoarthritis with erythema, often at the first metatarsophalangeal joint?
תשובה
Gout flare. Abrupt severe monoarthritis with erythema, often at the first metatarsophalangeal joint, suggests gout.
Gout · reviewed 2026-08-26
כרטיס 600
שאלה
For surgical decision-making, which diagnosis best fits this presentation: Exertional dyspnea, angina, or syncope with a harsh crescendo-decrescendo systolic murmur radiating to the carotids is typical.
תשובה
Symptomatic aortic stenosis. Exertional dyspnea, angina, or syncope with a harsh crescendo-decrescendo systolic murmur radiating to the carotids is typical.
2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease · reviewed 2026-08-26
600 כרטיסים
PANCE Flashcards: Blueprint-Aligned Diagnoses, Tests & Next Steps
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